New Perspectives for Fisetin

被引：101

作者：

Grynkiewicz, Grzegorz ^{[1
]}

Demchuk, Oleg M. ^{[1
]}

机构：

[1] Pharmaceut Res Inst, Warsaw, Poland

来源：

FRONTIERS IN CHEMISTRY | 2019年 / 7卷

关键词：

fisetin; flavon-3-ols; synthesis of flavonols; biological activity of flavonols; anti-cancer; anti-aging; CONDENSED TANNINS; CANCER PREVENTION; CHALCONE SYNTHASE; FLAVONOID FISETIN; FUNCTIONAL FOOD; LIFE-SPAN; CHEMISTRY; ANTIOXIDANT; METABOLISM; EVOLUTION;

D O I：

10.3389/fchem.2019.00697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules against stress which results in the sustenance of normal cells cytoprotection. Moreover, it shows potential as an anti-inflammatory, chemopreventive, chemotherapeutic and recently also senotherapeutic agent. In view of its prospective applications in healthcare and likely demand for fisetin, methods for its preparation and their suitability for pharmaceutical use are discussed herein.

引用

页数：10

共 87 条

[1] The chemical nature of phenolic compounds determines their toxicity and induces distinct physiological responses in Saccharomyces cerevisiae in lignocellulose hydrolysates [J].

Adeboye, Peter Temitope ;

Bettiga, Maurizio ;

Olsson, Lisbeth .

AMB EXPRESS, 2014, 4 :1-10

[2] A new synthesis of fisetin and of quercetin. [J].

Allan, J ;

Robinson, R .

JOURNAL OF THE CHEMICAL SOCIETY, 1926, :2334-2336

[3]

[Anonymous], 2015, Introduction to functional food science: Textbook

[4] The chalcone synthase superfamily of type III polyketide synthases [J].

Austin, MB ;

Noel, JP .

NATURAL PRODUCT REPORTS, 2003, 20 (01) :79-110

[5] Structure-activity study on the quinone/quinone methide chemistry of flavonoids [J].

Awad, HM ;

Boersma, MG ;

Boeren, S ;

van Bladeren, PJ ;

Vervoort, J ;

Rietjens, IMCM .

CHEMICAL RESEARCH IN TOXICOLOGY, 2001, 14 (04) :398-408

[6]

Baruah JB., 2011, Chemistry of phenolic compounds: state of the art

[7]

Bhalla Y, 2019, J Food Sci Technol, V4, P597

[8] Computational insight of the mechanism of Algar-Flynn-Oyamada (AFO) reaction [J].

Bhattacharyya, Shubhankar ;

Hatua, Kaushik .

RSC ADVANCES, 2014, 4 (36) :18702-18709

[9] Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs [J].

Borsari, Chiara ;

Luciani, Rosaria ;

Pozzi, Cecilia ;

Poehner, Ina ;

Henrich, Stefan ;

Trande, Matteo ;

Cordeiro-da-Silva, Anabela ;

Santarem, Nuno ;

Baptista, Catarina ;

Tait, Annalisa ;

Di Pisa, Flavio ;

Dello Iacono, Lucia ;

Landi, Giacomo ;

Gul, Sheraz ;

Wolf, Markus ;

Kuzikov, Maria ;

Ellinger, Bernhard ;

Reinshagen, Jeanette ;

Witt, Gesa ;

Gribbon, Philip ;

Kohler, Manfred ;

Keminer, Oliver ;

Behrens, Birte ;

Costantino, Luca ;

Nevado, Paloma Tejera ;

Bifeld, Eugenia ;

Eick, Julia ;

Clos, Joachim ;

Torrado, Juan ;

Jimenez-Anton, Maria D. ;

Corral, Maria J. ;

Ma Alunda, Jose ;

Pellati, Federica ;

Wade, Rebecca C. ;

Ferrari, Stefania ;

Mangani, Stefano ;

Costi, Maria Paola .

JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (16) :7598-7616

[10] Aging, Cellular Senescence, and Cancer [J].

Campisi, Judith .

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75, 2013, 75 :685-705

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