Cardiovascular risk factors and migraine - The GEM population-based study

被引:363
作者
Scher, AI
Terwindt, GM
Picavet, HSJ
Verschuren, WMM
Ferrari, MD
Launer, LJ
机构
[1] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD USA
[2] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands
[3] Ctr Prevent & Hlth Serv Res, Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands
关键词
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; QUALITY-OF-LIFE; CEREBRAL-ISCHEMIA; SUBSEQUENT RISK; BLOOD-PRESSURE; STROKE; ASSOCIATION; HEADACHE; HYPERTENSION; PREVALENCE;
D O I
10.1212/01.WNL.0000151857.43225.49
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this study, the authors compare the cardiovascular risk profile of adult migraineurs to that of nonmigraineurs. Methods: Participants (n = 5,755, 48% men, age 20 to 65 years) are from the Genetic Epidemiology of Migraine (GEM) study, a population-based study in the Netherlands. A total of 620 current migraineurs were identified: 31% with aura (MA), 64% without aura (MO), and 5% unclassified. Controls were 5,135 individuals without lifetime migraine. Measured cardiovascular risk factors included blood pressure (BP), serum total and high-density lipoprotein cholesterol (TC, HDL), smoking, oral contraceptive use, and the Framingham risk score for myocardial infarction or coronary heart disease (CHD) death. Results: Compared to controls, migraineurs were more likely to smoke (OR = 1.43 [1.1 to 1.8]), less likely to consume alcohol (OR = 0.58 [0.5 to 0.7]), and more likely to report a parental history of early myocardial infarction. Migraineurs with aura were more likely to have an unfavorable cholesterol profile (TC greater than or equal to 240 mg/dL [OR = 1.43 (0.97 to 2.1)], TC: HDL ratio > 5.0 [OR = 1.64 (1.1 to 2.4)]), have elevated BP (systolic BP > 140 mm Hg or diastolic BP > 90 mm Hg [OR = 1.76 (1.04 to 3.0)]), and report a history of early onset CHD or stroke (OR = 3.96 [1.1 to 14.3]); female migraineurs with aura were more likely to be using oral contraceptives (OR = 2.06 [1.05 to 4.0]). The odds of having an elevated Framingham risk score for CHD were approximately doubled for the migraineurs with aura. Conclusions: Migraineurs, particularly with aura, have a higher cardiovascular risk profile than individuals without migraine.
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收藏
页码:614 / 620
页数:7
相关论文
共 43 条
[1]   Potential source of cerebral embolism in migraine with aura - A transcranial Doppler study [J].
Anzola, GP ;
Magoni, M ;
Guindani, M ;
Rozzini, L ;
Dalla Volta, G .
NEUROLOGY, 1999, 52 (08) :1622-1625
[2]   MIGRAINE AND SUBSEQUENT RISK OF STROKE IN THE PHYSICIANS HEALTH STUDY [J].
BURING, JE ;
HEBERT, P ;
ROMERO, J ;
KITTROSS, A ;
COOK, N ;
MANSON, J ;
PETO, R ;
HENNEKENS, C .
ARCHIVES OF NEUROLOGY, 1995, 52 (02) :129-134
[3]   History of migraine and risk of cerebral ischaemia in young adults [J].
Carolei, A ;
Marini, C ;
DeMatteis, G ;
Fieschi, C ;
Frontoni, M ;
Zanette, E ;
Inzitari, D ;
Nencini, P ;
Gandolfo, C ;
Finocchi, C ;
Prencipe, M ;
Totaro, R ;
Landi, G ;
Motto, C ;
DeZanche, L ;
Parma, M ;
Scoditti, U .
LANCET, 1996, 347 (9014) :1503-1506
[4]  
Chang CL, 1999, BMJ-BRIT MED J, V318, P13
[5]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[6]   Migraine and coronary heart disease in women and men [J].
Cook, NR ;
Benseñor, IM ;
Lotufo, PA ;
Lee, IM ;
Skerrett, PJ ;
Chown, MJ ;
Ajani, UA ;
Manson, JE ;
Buring, JE .
HEADACHE, 2002, 42 (08) :715-727
[7]   Migraine [J].
Ferrari, MD .
LANCET, 1998, 351 (9108) :1043-1051
[8]  
FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1
[9]  
Hagen K, 2002, J NEUROL NEUROSUR PS, V72, P463
[10]   Trends in total and high density lipoprotein cholesterol and their determinants in The Netherlands between 1993 and 1997 [J].
Houterman, S ;
Verschuren, WMM ;
Oomen, CM ;
Boersma-Cobbaert, CM ;
Kromhout, D .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 (05) :1063-1070