Autoimmunity in obstetrics and autoimmune diseases in pregnancy

被引：24

作者：

De Carolis, Sara ^{[1
,4
]}

Moresi, Sascia ^{[1
]}

Rizzo, Francesca ^{[1
]}

Monteleone, Giuseppina ^{[1
]}

Tabacco, Sara ^{[2
]}

Salvi, Silvia ^{[1
]}

Garufi, Cristina ^{[3
]}

Lanzone, Antonio ^{[1
,4
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, UOC Patol Ostetr, Dipartimento Sci Salute Donna Bambino & Sanita Pu, Rome, Italy

[2] Sapienza Univ Roma, Umberto I Hosp, Dept Gynecol & Obstet Sci & Urol Sci, Rome, Italy

[3] Sapienza Univ Roma, Umberto I Hosp, Lupus Clin, Dipartimento Med Intema & Special Med, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Ist Clin Ostetr & Ginecol, Rome, Italy

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2019年 / 60卷

关键词：

APS; SLE; Pregnancy; IUGR; Fetal loss; PRIMARY SJOGRENS-SYNDROME; ANTIPHOSPHOLIPID SYNDROME; HEART-BLOCK; FETAL; WOMEN; OUTCOMES; LUPUS; REPRODUCTION; PREDICTORS; STANDARD;

D O I：

10.1016/j.bpobgyn.2019.03.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Autoimmune diseases (AIDS) are associated with strong female preponderance and often present before or during the reproductive years; consequently, pregnancy and breastfeeding are topics of major interest for these patients. AIDs show different responses to pregnancy: some ameliorate, while others remain unchanged, and several AIDS aggravate. The response of the AIDS to the hormonal and immunological alterations of pregnancy reflects the different pathophysiology of each disease. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with multiple autoantibodies, multiorgan involvement, more aggressive therapy, and increased impact on pregnancy outcome. For the management of pregnancy in patients with SLE and/or APS, it is important to individuate the correct risk profile for each woman and timing for treatment. The optimal timing for starting or modulating treatment is at preconception assessment to influence the placentation. In this chapter, we discuss the management of pregnancy in patients with AIDs. (C) 2019 Published by Elsevier Ltd.

引用

页码：66 / 76

页数：11

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