ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS

被引：485
作者：
Bruderer, M. [1 ]
Richards, R. G. [1 ]
Alini, M. [1 ]
Stoddart, M. J. [1 ]
机构：
[1] AO Res Inst Davos, CH-7270 Davos, Switzerland
来源：
EUROPEAN CELLS & MATERIALS | 2014年 / 28卷
关键词：
Stem cells; bone; osteogenesis; differentiation; transcription factor; RUNX2; BONE MORPHOGENETIC PROTEIN-2; TRANSCRIPTION FACTOR CBFA1; CORE-BINDING-FACTOR; OSTEOCALCIN GENE-EXPRESSION; GROWTH-FACTOR-BETA; OSTEOBLAST DIFFERENTIATION; CLEIDOCRANIAL DYSPLASIA; COLLAGENASE-3; PROMOTER; DEPENDENT ACTIVATION; HISTONE ACETYLATION;
D O I：
10.22203/eCM.v028a19
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.
引用
收藏
页码：269 / 286
页数：18
相关论文
共 168 条
[1]   Function of CBFβ/Bro proteins [J].
Adya, N ;
Castilla, LH ;
Liu, PP .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2000, 11 (05) :361-368
[2]   TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].
Alliston, T ;
Choy, L ;
Ducy, P ;
Karsenty, G ;
Derynck, R .
EMBO JOURNAL, 2001, 20 (09) :2254-2272
[3]   Groucho-dependent and -independent repression activities of runt domain proteins [J].
Aronson, BD ;
Fisher, AL ;
Blechman, K ;
Caudy, M ;
Gergen, JP .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (09) :5581-5587
[4]  
BAE SC, 1993, ONCOGENE, V8, P809
[5]   CLONING, MAPPING AND EXPRESSION OF PEBP2-ALPHA-C, A 3RD GENE ENCODING THE MAMMALIAN RUNT DOMAIN [J].
BAE, SC ;
TAKAHASHI, E ;
ZHANG, YW ;
OGAWA, E ;
SHIGESADA, K ;
NAMBA, Y ;
SATAKE, M ;
ITO, Y .
GENE, 1995, 159 (02) :245-248
[6]   PEBP2-ALPHA-B/MOUSE AML1 CONSISTS OF MULTIPLE ISOFORMS THAT POSSESS DIFFERENTIAL TRANSACTIVATION POTENTIALS [J].
BAE, SC ;
OGAWA, E ;
MARUYAMA, M ;
OKA, H ;
SATAKE, M ;
SHIGESADA, K ;
JENKINS, NA ;
GILBERT, DJ ;
COPELAND, NG ;
ITO, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3242-3252
[7]   Differential regulation of the two principal Runx2/Cbfa1 N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype [J].
Banerjee, C ;
Javed, A ;
Choi, JY ;
Green, J ;
Rosen, V ;
van Wijnen, AJ ;
Stein, JL ;
Lian, JB ;
Stein, GS .
ENDOCRINOLOGY, 2001, 142 (09) :4026-4039
[8]  
Banerjee C, 1997, J CELL BIOCHEM, V66, P1, DOI 10.1002/(SICI)1097-4644(19970701)66:1<1::AID-JCB1>3.0.CO
[9]  
2-V
[10]   ROLE OF ACTIVE AND LATENT TRANSFORMING GROWTH-FACTOR-BETA IN BONE-FORMATION [J].
BONEWALD, LF ;
DALLAS, SL .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 55 (03) :350-357
12345678910