Delivery of RNA Nanoparticles into Colorectal Cancer Metastases Following Systemic Administration

被引：75

作者：

Rychahou, Piotr ^{[1
,2
]}

Haque, Farzin ^{[4
,5
]}

Shu, Yi ^{[4
,5
]}

Zaytseva, Yekaterina ^{[1
]}

Weiss, Heidi L. ^{[1
]}

Lee, Eun Y. ^{[1
,2
,3
]}

Mustain, William ^{[2
]}

Valentino, Joseph ^{[2
]}

Guo, Peixuan ^{[1
,4
,5
]}

Evers, B. Mark ^{[1
,2
]}

机构：

[1] Univ Kentucky, Lucille P Markey Canc Ctr, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Surg, Lexington, KY 40536 USA

[3] Univ Kentucky, Lexington, KY 40536 USA

[4] Univ Kentucky, Nanobiotechnol Ctr, Lexington, KY 40536 USA

[5] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA

来源：

ACS NANO | 2015年 / 9卷 / 02期

关键词：

colorectal cancer; metastasis; nanobiotechnology; bacteriophage phi29; RNA nanoparticle; RNA therapeutics; PHI29 PRNA NANOPARTICLES; DRUG-DELIVERY; THERAPEUTIC RNAS; SIRNA; TUMOR; CELLS; ACCUMULATION; MICROSPONGES; FABRICATION; STATISTICS;

D O I：

10.1021/acsnano.5b00067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The majority of deaths from all cancers, including colorectal cancer (CRC), is a result of tumor metastasis to distant organs. To date, an effective and safe system capable of exclusively targeting metastatic cancers that have spread to distant organs or lymph nodes does not exist. Here, we constructed multifunctional RNA nanoparticles, derived from the three-way junction (3WJ) of bacteriophage phi29 motor pRNA, to target metastatic cancer cells in a clinically relevant mouse model of CRC metastasis. The RNA nanoparticles demonstrated metastatic tumor homing without accumulation in normal organ tissues surrounding metastatic tumors. The RNA nanoparticles simultaneously targeted CRC cancer cells in major sites of metastasis, such as liver, lymph nodes, and lung. Our results demonstrate the therapeutic potential of these RNA nanoparticles as a delivery system for the treatment of CRC metastasis.

引用

页码：1108 / 1116

页数：9

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