Mass Spectrometry for Paper-Based Immunoassays: Toward On-Demand Diagnosis

被引：113

作者：

Chen, Suming ^{[1
]}

Wan, Qiongqiong ^{[1
]}

Badu-Tawiah, Abraham K. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 20期

关键词：

CARE DIAGNOSTICS; POINT; PROTEINS; DEVICES; FUTURE; ASSAYS; SPRAY;

D O I：

10.1021/jacs.6b02232

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Current analytical methods, either point-of-care or centralized detection, are not able to meet recent demands of patient-friendly testing and increased reliability of results. Here, we describe a two-point separation on-demand diagnostic strategy based on a paper-based mass spectrometry immunoassay platform that adopts stable and cleavable ionic probes as mass reporter; these probes make possible sensitive, interruptible, storable, and restorable on-demand detection. In addition, a new touch paper spray method was developed for on-chip, sensitive, and cost-effective analyte detection. This concept is successfully demonstrated via (i) the detection of Plasmodium falciparum histidine-rich protein 2 antigen and (ii) multiplexed and simultaneous detection of cancer antigen 125 and carcinoembryonic antigen.

引用

页码：6356 / 6359

页数：4

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