Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry

被引：10
作者：
Vallard, Alexis [1 ]
Guy, Jean-Baptiste [1 ]
Ndong, Sylvie Mengue [1 ]
Vial, Nicolas [1 ]
Rivoirard, Romain [2 ]
Auberdiac, Pierre [3 ]
Mery, Benoite [2 ]
Langrand-Escure, Julien [1 ]
Espenel, Sophie [1 ]
Moncharmont, Coralie [1 ]
Ben Mrad, Majed [1 ]
Diao, Peng [1 ]
Goyet, Dominique [4 ]
Magne, Nicolas [1 ]
机构：
[1] Lucien Neuwirth Canc Inst, Dept Radiotherapy, 108 Bis,Ave Albert Raimond,BP 60008, F-42271 St Priest En Jarez, France
[2] Lucien Neuwirth Canc Inst, Dept Med Oncol, St Priest En Jarez, France
[3] Claude Bernard Clin, Dept Radiotherapy, Albi, France
[4] Lucien Neuwirth Canc Inst, Dept Med Phys, St Priest En Jarez, France
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 07期
关键词：
volumetric-modulated arc therapies; intensity-modulated radiotherapy; parotid gland; submandibular gland; dosimetry; LOCALLY ADVANCED HEAD; RADIATION-THERAPY; PAROTID-GLAND; IMRT; XEROSTOMIA; AMIFOSTINE;
D O I：
10.1002/hed.24398
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Despite radiotherapy (RT) technical improvements, high salivary dysfunction rates are still reported in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of the present study was to report salivary glands dosimetry with volumetric-modulated arc therapy (VMAT) and intensity-modulated RT (IMRT). Methods. Dosimetry of consecutive patients receiving IMRT or VMAT for proven HNSCC between 2007 and 2013 were retrospectively reviewed. Results. Data of 609 patients were studied. Mean dose, mean maximum dose, and mean percentage of salivary gland volume receiving at least 26 Gy (V26) of the contralateral parotid were 24.50 Gy (range, 0-70.4 Gy), 39.08 Gy (range, 0.38-76.45 Gy), and 40.92% (range, 0% to 100%), respectively. Mean and maximum dose on contralateral submandibular gland were 48.18 Gy (range, 0.19-70.73 Gy), and 61.25 Gy (range, 0-75.8 Gy), respectively. Conclusion. Target volume coverage still has to be prioritized over organs at risk (OAR) sparing with new RT techniques. Submandibular glands are not sufficiently taken into account in guidelines. (C) 2016 Wiley Periodicals, Inc.
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收藏
页码：1028 / 1034
页数：7
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