Self-emulsifying drug-delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects

被引：12
作者：
AboulFotouh, Khaled [1 ]
Allam, Ayat A. [1 ]
El-Badry, Mahmoud [1 ]
El-Sayed, Ahmed M. [1 ]
机构：
[1] Assiut Univ, Fac Pharm, Dept Pharmaceut, Assiut 71526, Egypt
来源：
NANOMEDICINE | 2018年 / 13卷 / 14期
关键词：
cancer; effective concentration range; multidrug resistance (MDR); IMPROVED ORAL BIOAVAILABILITY; VITAMIN-E TPGS; IN-VITRO; MULTIDRUG-RESISTANCE; INTESTINAL-ABSORPTION; PHARMACEUTICAL EXCIPIENTS; CACO-2; CELLS; NANOEMULSIFYING FORMULATION; FUNCTIONAL EXCIPIENT; IMPROVED DISSOLUTION;
D O I：
10.2217/nnm-2017-0354
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Self-emulsifying drug-delivery systems (SEDDS) have been widely employed to ameliorate the oral bioavailability of P-glycoprotein (P-gp) substrate drugs and to overcome multidrug resistance in cancer cells. However, the role of formulation aspects in the reduced P-gp activity is not fully understood. In this review, we first explore the role of various SEDDS excipients in the reduced P-gp activity with the main emphasis on the effective excipient concentration range for excipient-mediated modulation of P-gp activity and then we discuss the synergistic effect of various formulation aspects on the excipient-mediated modulation of P-gp activity. This review provides an approach to develop a rationally designed SEDDS to overcome P-gp-mediated drug efflux.
引用
收藏
页码：1813 / 1834
页数：22
相关论文
共 118 条
[1]   Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability [J].
AboulFotouh, Khaled ;
Allam, Ayat A. ;
El-Badry, Mahmoud ;
El-Sayed, Ahmed M. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 167 :82-92
[2]   Development and in vitro/in vivo performance of self-nanoemulsifying drug delivery systems loaded with candesartan cilexetil [J].
AboulFotouh, Khaled ;
Allam, Ayat A. ;
El-Badry, Mahmoud ;
El-Sayed, Ahmed M. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 109 :503-513
[3]   Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery [J].
Afonso-Pereira, Francisco ;
Dou, Liu ;
Trenfield, Sarah J. ;
Madla, Christine M. ;
Murdan, Sudaxshina ;
Sousa, Joao ;
Veiga, Francisco ;
Basit, Abdul W. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 115 :339-344
[4]   Self-Nanoemulsifying Lipid Carrier System for Enhancement of Oral Bioavailability of Etoposide by P-Glycoprotein Modulation: In Vitro Cell Line and In Vivo Pharmacokinetic Investigation [J].
Akhtar, Naseem ;
Talegaonkar, Sushama ;
Khar, Roop K. ;
Jaggi, Manu .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013, 9 (07) :1216-1229
[5]   The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review [J].
Akhtar, Naseem ;
Ahad, Abdul ;
Khar, Roop Kishan ;
Jaggi, Manu ;
Aqil, Mohammed ;
Iqbal, Zeenat ;
Ahmad, Farhan Jalees ;
Talegaonkar, Sushama .
EXPERT OPINION ON THERAPEUTIC PATENTS, 2011, 21 (04) :561-576
[6]   Effect of pharmaceutical excipients on the permeability of P-glycoprotein substrate [J].
Al-Mohizea, A. M. ;
Zawaneh, F. ;
Alam, M. A. ;
Al-Jenoobi, F. I. ;
El-Maghraby, G. M. .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2014, 24 (05) :491-495
[7]   Anticancer Efficacy of Self-Nanoemulsifying Drug Delivery System of Sunitinib Malate [J].
Alshahrani, Saad M. ;
Alshetaili, Abdullah S. ;
Alalaiwe, Ahmed ;
Alsulays, Bader B. ;
Anwer, Md Khalid ;
Al-Shdefat, Ramadan ;
Imam, Faisal ;
Shakeel, Faiyaz .
AAPS PHARMSCITECH, 2018, 19 (01) :123-133
[8]   Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences [J].
Anton, Nicolas ;
Vandamme, Thierry F. .
PHARMACEUTICAL RESEARCH, 2011, 28 (05) :978-985
[9]   Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism [J].
Arya, Abhishek ;
Ahmad, Hafsa ;
Tulsankar, Sachin ;
Agrawal, Satish ;
Mittapelly, Naresh ;
Boda, Rajkumar ;
Bhatta, Rabi S. ;
Mitra, Kalyan ;
Dwivedi, Anil K. .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 71 :954-964
[10]   Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models [J].
Babu, P. Ravindra ;
Babu, K. Naveen ;
Peter, P. L. Haroled ;
Rajesh, K. ;
Babu, P. Jawahar .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2013, 39 (06) :873-879
12345678910