Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

被引：23

作者：

Blanco, Ayelen M. ^{[1
,2
,3
]}

Velasco, Cristina ^{[1
,2
,3
]}

Bertucci, Juan, I ^{[1
,4
]}

Soengas, Jose L. ^{[2
,3
]}

Unniappan, Suraj ^{[1
]}

机构：

[1] Univ Saskatchewan, Lab Integrat Neuroendocrinol, Dept Vet Biomed Sci, Western Coll Vet Med, Saskatoon, SK, Canada

[2] Univ Vigo, Lab Fisiol Anim, Dept Biol Func & Ciencias Saude, Fac Biol, Vigo, Spain

[3] Univ Vigo, Ctr Invest Marina, Vigo, Spain

[4] Inst Tecnol Chascomus, Inst Invest Biotecnol, Chascomus, Argentina

来源：

FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

NUCB2; nutrient sensing; hypothalamus; hindbrain; liver; fish; GOLDFISH CARASSIUS-AURATUS; FOOD-INTAKE REGULATION; ACID-SENSING SYSTEMS; ENERGY HOMEOSTASIS; BROCKMANN BODIES; BODY-WEIGHT; FATTY-ACIDS; HEPATIC GLUCONEOGENESIS; DEPENDENT MODULATION; ONCORHYNCHUS-MYKISS;

D O I：

10.3389/fendo.2018.00484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nesfatin-1 is an 82 amino acid peptide that has been involved in a wide variety of physiological functions in both mammals and fish. This study aimed to elucidate the role of nesfatin-1 on rainbow trout food intake, and its putative effects on glucose and fatty acid sensing systems. Intracerebroventricular administration of 25 ng/g nesfatin-1 resulted in a significant inhibition of appetite, likely mediated by the activation of central POMC and CART. Nesfatin-1 stimulated the glucosensing machinery (changes in sglt1, g6pase, gsase, and gnat3 mRNA expression) in the hindbrain and hypothalamus. Central fatty acid sensing mechanisms were unaltered by nesfatin-1, but this peptide altered the expression of mRNAs encoding factors regulating lipid metabolism (fat/cd36, acly, mcd, fas, lpl, ppar alpha, and ppar gamma), suggesting that nesfatin-1 promotes lipid accumulation in neurons. In the liver, intracerebroventricular nesfatin-1 treatment resulted in decreased capacity for glucose use and lipogenesis, and increased the potential of fatty acid oxidation. Altogether, the present results demonstrate that nesfatin-1 is involved in the homeostatic regulation of food intake and metabolism in fish.

引用

页数：12

共 78 条

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