Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides

被引：51
|
作者：
Sheng, Jie
Ni, Hui-Qi
Liu, Ge
Li, Yan
Wang, Xi-Sheng [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 17期
基金：
美国国家科学基金会;
关键词：
CROSS-COUPLING REACTIONS; CARBON BOND FORMATION; ARYLBORONIC ACIDS; (2-PYRIDYL)SULFONYL GROUP; BENZYLIC FLUORINATION; ASYMMETRIC CATALYSIS; FLUOROMETHYL IODIDE; MEDICINAL CHEMISTRY; EMISSION-TOMOGRAPHY; EFFICIENT SYNTHESIS;
D O I：
10.1021/acs.orglett.7b02012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A combinatorial nickel-catalyzed cross-coupling between arylboronic acids and unactived 1-fluoro-1-iodoalkanes has been developed, which demonstrated high efficiency, mild conditions, and excellent functional-group compatibility. Readily available nitrogen and phosphine ligands were combined with a nitrogen source, which in situ generated a variety of easily tunable catalysts to promote the fluoroalkylation for broad scopes of both coupling partners. This new strategy on combinatorial catalysis offers new solutions for nickel-catalyzed cross-coupling reactions.
引用
收藏
页码：4480 / 4483
页数：4
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