Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides

被引：52

作者：

Sheng, Jie

Ni, Hui-Qi

Liu, Ge

Li, Yan

Wang, Xi-Sheng ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 17期

基金：

美国国家科学基金会;

关键词：

CROSS-COUPLING REACTIONS; CARBON BOND FORMATION; ARYLBORONIC ACIDS; (2-PYRIDYL)SULFONYL GROUP; BENZYLIC FLUORINATION; ASYMMETRIC CATALYSIS; FLUOROMETHYL IODIDE; MEDICINAL CHEMISTRY; EMISSION-TOMOGRAPHY; EFFICIENT SYNTHESIS;

D O I：

10.1021/acs.orglett.7b02012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combinatorial nickel-catalyzed cross-coupling between arylboronic acids and unactived 1-fluoro-1-iodoalkanes has been developed, which demonstrated high efficiency, mild conditions, and excellent functional-group compatibility. Readily available nitrogen and phosphine ligands were combined with a nitrogen source, which in situ generated a variety of easily tunable catalysts to promote the fluoroalkylation for broad scopes of both coupling partners. This new strategy on combinatorial catalysis offers new solutions for nickel-catalyzed cross-coupling reactions.

引用

页码：4480 / 4483

页数：4

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