Peri-Coronary Adipose Tissue Density Is Associated With 18F-Sodium Fluoride Coronary Uptake in Stable Patients With High-Risk Plaques

被引:149
作者
Kwiecinski, Jacek [1 ,2 ]
Dey, Damini [1 ]
Cadet, Sebastien [1 ]
Lee, Sang-Eun [3 ]
Otaki, Yuka [1 ]
Huynh, Phi T. [1 ]
Doris, Mhairi K. [2 ]
Eisenberg, Evann [1 ]
Yun, Mijin [3 ]
Jansen, Maurits A. [2 ]
Williams, Michelle C. [2 ]
Tamarappoo, Balaji K. [1 ]
Friedman, John D. [1 ]
Dweck, Marc R. [1 ]
Newby, David E. [2 ]
Chang, Hyuk-Jae [3 ]
Slomka, Piotr J. [1 ]
Berman, Daniel S. [1 ]
机构
[1] Cedars Sinai Med Ctr, Dept Imaging Med & Biomed Sci, Div Nucl Med, Los Angeles, CA 90048 USA
[2] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland
[3] Yonsei Univ, Coll Med, Severance Cardiovasc Hosp, Seoul, South Korea
基金
英国惠康基金;
关键词
F-18-sodium fluoride; coronary computed tomography angiography; coronary imaging; high-risk plaque; PET/CT; peri-coronary adipose tissue density; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; CT ANGIOGRAPHY; PREDICTION; CALCIUM; EVENTS;
D O I
10.1016/j.jcmg.2018.11.032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES This study aimed to assess the association between increased lesion pen-coronary adipose tissue (PCAT) density and coronary F-18-sodium fluoride (F-18-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA). BACKGROUND Coronary F-18-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflammation. Currently, the relationship between increased PCAT density and F-18-NaF uptake in stable patients with HRPs on coronary CTA has not been characterized. METHODS Patients who underwent coronary CTA were screened for HRP, which was defined by 3 concurrent plaque features: positive remodeling; low attenuation plaque (LAP) (<30 Hounsfield units [HU]) and spotty calcification; and obstructive coronary stenosis >= 50% (plaque volume >100 mm(3)). Patients with HRPs were recruited to undergo F-18-NaF PET/CT. In lesions with stenosis >= 25%, quantitative plaque analysis, mean PCAT density, maximal coronary motion-corrected F-18-NaF standard uptake values (SUVmax), and target-to-background ratios (TBR) were measured. RESULTS Forty-one patients (age 65 +/- 16 years; 68% men) were recruited. Fifty-one lesions in 23 patients (56%) showed increased coronary F-18-NaF activity. Lesions with F-18-NaF uptake had higher surrounding PCAT density than those without F-18-NaF uptake (-73 HU; interquartile range 79 to 68 HU vs. 86 HU; interquartile range 94 to 80 HU; p < 0.001). F-18-NaF TBR and SUVmax were correlated with PCAT density (r 0.63 and r 0.68, respectively; all p < 0.001). On adjusted multiple regression analysis, increased lesion PCAT density and LAP volume were associated with F-18-NaF TBR (beta = 0.25; 95% confidence interval: 0.17 to 0.34; p < 0.001 for PCAT, and (beta = 0.07; 95% confidence interval: 0.03 to 0.11; p = 0.002 for LAP). CONCLUSIONS In patients with HRP features on coronary CTA, increased density of PCAT was associated with focal F-18-NaF PET uptake. Simultaneous assessment of these imaging biomarkers by F-18-NaF PET and CTA might refine cardiovascular risk prediction in stable patients with HRP features. (C) 2019 by the American College of Cardiology Foundation.
引用
收藏
页码:2000 / 2010
页数:11
相关论文
共 26 条
  • [1] QUANTIFICATION OF CORONARY-ARTERY CALCIUM USING ULTRAFAST COMPUTED-TOMOGRAPHY
    AGATSTON, AS
    JANOWITZ, WR
    HILDNER, FJ
    ZUSMER, NR
    VIAMONTE, M
    DETRANO, R
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 15 (04) : 827 - 832
  • [2] Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Aikawa, Elena
    Nahrendorf, Matthias
    Figueiredo, Jose-Luiz
    Swirski, Filip K.
    Shtatland, Timur
    Kohler, Rainer H.
    Jaffer, Farouc A.
    Aikawa, Masanori
    Weissleder, Ralph
    [J]. CIRCULATION, 2007, 116 (24) : 2841 - 2850
  • [3] Detecting human coronary inflammation by imaging perivascular fat
    Antonopoulos, Alexios S.
    Sanna, Fabio
    Sabharwal, Nikant
    Thomas, Sheena
    Oikonomou, Evangelos K.
    Herdman, Laura
    Margaritis, Marios
    Shirodaria, Cheerag
    Kampoli, Anna-Maria
    Akoumianakis, Ioannis
    Petrou, Mario
    Sayeed, Rana
    Krasopoulos, George
    Psarros, Constantinos
    Ciccone, Patricia
    Brophy, Carl M.
    Digby, Janet
    Kelion, Andrew
    Uberoi, Raman
    Anthony, Suzan
    Alexopoulos, Nikolaos
    Tousoulis, Dimitris
    Achenbach, Stephan
    Neubauer, Stefan
    Channon, Keith M.
    Antoniades, Charalambos
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (398)
  • [4] Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Detrano, Robert
    Guerci, Alan D.
    Carr, J. Jeffrey
    Bild, Diane E.
    Burke, Gregory
    Folsom, Aaron R.
    Liu, Kiang
    Shea, Steven
    Szklo, Moyses
    Bluemke, David A.
    O'Leary, Daniel H.
    Tracy, Russell
    Watson, Karol
    Wong, Nathan D.
    Kronmal, Richard A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (13) : 1336 - 1345
  • [5] DORIS MK, 2018, J NUCL CARDIOL
  • [6] High-Risk Coronary Plaque on Computed Tomography Angiography Time to Recognize a New Imaging Risk Factor
    Ferencik, Maros
    Hoffmann, Udo
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2018, 11 (01)
  • [7] Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain A Secondary Analysis of the PROMISE Randomized Clinical Trial
    Ferencik, Maros
    Mayrhofer, Thomas
    Bittner, Daniel O.
    Emami, Hamed
    Puchner, Stefan B.
    Lu, Michael T.
    Meyersohn, Nandini M.
    Ivanov, Alexander V.
    Adami, Elizabeth C.
    Patel, Manesh R.
    Mark, Daniel B.
    Udelson, James E.
    Lee, Kerry L.
    Douglas, Pamela S.
    Hoffmann, Udo
    [J]. JAMA CARDIOLOGY, 2018, 3 (02) : 144 - 152
  • [8] Pericoronary Adipose Tissue Computed Tomography Attenuation and High-Risk Plaque characteristics in Acute Coronary Syndrome Compared With Stable Coronary Artery Disease
    Goeller, Markus
    Achenbach, Stephan
    Cadet, Sebastien
    Kwan, Alan C.
    Commandeur, Frederic
    Slomka, Piotr J.
    Gransar, Heidi
    Albrecht, Moritz H.
    Tamarappoo, Balaji K.
    Berman, Daniel S.
    Marwan, Mohamed
    Dey, Damini
    [J]. JAMA CARDIOLOGY, 2018, 3 (09) : 858 - 863
  • [9] Perivascular Epicardial Fat Stranding at Coronary CT Angiography: A Marker of Acute Plaque Rupture and Spontaneous Coronary Artery Dissection
    Hedgire, Sandeep
    Baliyan, Vinit
    Zucker, Evan J.
    Bittner, Daniel O.
    Staziaki, Pedro V.
    Takx, Richard A. P.
    Scholtz, Jan-Erik
    Meyersohn, Nandini
    Hoffmann, Udo
    Ghoshhajra, Brian
    [J]. RADIOLOGY, 2018, 287 (03) : 808 - 815
  • [10] Quantitative global plaque characteristics from coronary computed tomography angiography for the prediction of future cardiac mortality during long-term follow-up
    Hell, Michaela M.
    Motwani, Manish
    Otaki, Yuka
    Cadet, Sebastien
    Gransar, Heidi
    Miranda-Peats, Romalisa
    Valk, Jacob
    Slomka, Piotr J.
    Cheng, Victor Y.
    Rozanski, Alan
    Tamarappoo, Balaji K.
    Hayes, Sean
    Achenbach, Stephan
    Berman, Daniel S.
    Dey, Damini
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2017, 18 (12) : 1331 - 1339