Plasma fibrinogen in non insulin dependent diabetes mellitus patients of Tucuman

Early development of coronary disease in Non Insulin Dependent Diabetes Mellitus (NIDDM), plasma fibrinogen bevels and its relations with other risk markers were determinated in diabetic patients of San Miguel de Tucuman. 97 NIDDM patients of both ser, and aged from 37 to 65 years, were studied and matched with a control group of 50 healthy subjects, in which plasma Fg, glycemia, fructosamine and lipid profile were determinated. Plasma Fg levels in diabetic patients were 320 +/- 87 mg/dl and 328 +/- 73 mg/dl in women. There were significant difference with control group (men: 257 +/- 48, p< 0,005; women: 256 +/- 38, p< 0.005). Lipid profile of diabetic men showed that total cholesterol and LDL-cholesterol values were statistically lower than diabetic women (p< 0,005 and p< 0,05 respectively), in which an significant and inverse relation between Fg and triglicerides runs observed. FR was higher in hypertensive patients than those normal arterial tension (men: 324 +/- 49 vs 317 +/- 57 mg/dl; women: 328 +/- 46 vs 309 +/- 54 mg/dl). Significant variations were not observed between Fg and age, neither evolution time of disease, smoker and nor smoker, alcohol drinker and not drinker diabetic men. We concluded that increased Fg levels in NIDDM confirm that it is an independent risk marker of cardiovascular disease associated to diabetes.