The mitochondrial genome in aging and senescence

被引：57

作者：

Lauri, Andrea ^{[1
]}

Pompilio, Giulio ^{[1
]}

Capogrossi, Maurizio C. ^{[2
]}

机构：

[1] IRCCS, CCM, Lab Biol Vasc & Med Rigenerat, Milan, Italy

[2] IRCCS, IDI, Lab Patol Vasc, Milan, Italy

来源：

AGEING RESEARCH REVIEWS | 2014年 / 18卷

关键词：

Aging; Senescence; Mitochondria; mtDNA; ROS; Molecular mechanisms; TELOMERASE REVERSE-TRANSCRIPTASE; CYTOCHROME-C-OXIDASE; P53; TUMOR-SUPPRESSOR; MAXIMUM LIFE-SPAN; DNA-DAMAGE; OXIDATIVE STRESS; POINT MUTATIONS; CELLULAR SENESCENCE; GENE-EXPRESSION; REPAIR CAPACITY;

D O I：

10.1016/j.arr.2014.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence. In this review we examine the role of mitochondrial dysfunction and mtDNA mutations in cell aging and senescence. Specifically, we address how p53 and telomerase reverse transcriptase (TERT) activity switch their roles from cytoprotective to detrimental and also examine the role of microRNAs in cell aging. The proposed role of Reactive Oxygen Species (ROS), both as mutating agents and as signalling molecules, underlying these processes is also described. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 15

页数：15

共 199 条

[1] Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ [J].

Achanta, G ;

Sasaki, R ;

Feng, L ;

Carew, JS ;

Lu, WQ ;

Pelicano, H ;

Keating, MJ ;

Huang, P .

EMBO JOURNAL, 2005, 24 (19) :3482-3492

[2] Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice [J].

Ahlqvist, Kati J. ;

Hamalainen, Riikka H. ;

Yatsuga, Shuichi ;

Uutela, Marko ;

Terzioglu, Mugen ;

Gotz, Alexandra ;

Forsstrom, Saara ;

Salven, Petri ;

Angers-Loustau, Alexandre ;

Kopra, Outi H. ;

Tyynismaa, Henna ;

Larsson, Nils-Goran ;

Wartiovaara, Kirmo ;

Prolla, Tomas ;

Trifunovic, Aleksandra ;

Suomalainen, Anu .

CELL METABOLISM, 2012, 15 (01) :100-109

[3] Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress [J].

Ahmed, Shaheda ;

Passos, Joao F. ;

Birket, Matthew J. ;

Beckmann, Tina ;

Brings, Sebastian ;

Peters, Heiko ;

Birch-Machin, Mark A. ;

von Zglinicki, Thomas ;

Saretzki, Gabriele .

JOURNAL OF CELL SCIENCE, 2008, 121 (07) :1046-1053

[4] The function of genomes in bioenergetic organelles [J].

Allen, JF .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2003, 358 (1429) :19-37

[5] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].

ALLSOPP, RC ;

VAZIRI, H ;

PATTERSON, C ;

GOLDSTEIN, S ;

YOUNGLAI, EV ;

FUTCHER, AB ;

GREIDER, CW ;

HARLEY, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118

[6] Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins [J].

Ameur, Adam ;

Stewart, James B. ;

Freyer, Christoph ;

Hagstrom, Erik ;

Ingman, Max ;

Larsson, Nils-Goran ;

Gyllensten, Ulf .

PLOS GENETICS, 2011, 7 (03)

[7] Glutamine, as a precursor of glutathione, and oxidative stress [J].

Amores-Sánchez, MI ;

Medina, MA .

MOLECULAR GENETICS AND METABOLISM, 1999, 67 (02) :100-105

[8] p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance [J].

Aquilano, Katia ;

Baldelli, Sara ;

Pagliei, Beatrice ;

Cannata, Stefano M. ;

Rotilio, Giuseppe ;

Ciriolo, Maria R. .

ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (04) :386-399

[9] The structure and function of telomerase reverse transcriptase [J].

Autexier, Chantal ;

Lue, Neal F. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :493-517

[10] miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes [J].

Bai, Xue-Yuan ;

Ma, Yuxiang ;

Ding, Rui ;

Fu, Bo ;

Shi, Suozhu ;

Chen, Xiang-Mei .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (07) :1252-1261

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