Mitochondrial superoxide: a key player in Alzheimer's disease

被引：44
作者：
Massaad, Cynthia A. [1 ]
Pautler, Robia G. [1 ]
Klann, Eric [2 ]
机构：
[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA
[2] NYU, Ctr Neural Sci, New York, NY 10003 USA
来源：
AGING-US | 2009年 / 1卷 / 09期
关键词：
Alzheimer's disease; Tg2576; SOD-2; Oxidative Stress; Mitochondria; TARGETED PLASTOQUINONE DERIVATIVES; AMYLOID PRECURSOR PROTEIN; OXIDATIVE STRESS; INTERRUPT EXECUTION; MOUSE MODEL; TOOLS; MEMORY; MICE; OVEREXPRESSION; REDUCTION;
D O I：
10.18632/aging.100088
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
[No abstract available]
引用
收藏
页码：758 / 761
页数：4
相关论文
共 26 条
  • [1] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells
    Agapova, L. S.
    Chernyak, B. V.
    Domnina, L. V.
    Dugina, V. B.
    Efimenko, A. Yu.
    Fetisova, E. K.
    Ivanova, O. Yu.
    Kalinina, N. I.
    Khromova, N. V.
    Kopnin, B. P.
    Kopnin, P. B.
    Korotetskaya, M. V.
    Lichinitser, M. R.
    Lukashev, A. L.
    Pletjushkina, O. Yu.
    Popova, E. N.
    Skulachev, M. V.
    Shagieva, G. S.
    Stepanova, E. V.
    Titova, E. V.
    Tkachuk, V. A.
    Vasiliev, J. M.
    Skulachev, V. P.
    [J]. BIOCHEMISTRY-MOSCOW, 2008, 73 (12) : 1300 - 1316
  • [2] Protective effects of mitochondria-targeted antioxidant SkQ in aqueous and lipid membrane environments
    Antonenko, Y. N.
    Roginsky, V. A.
    Pashkovskaya, A. A.
    Rokitskaya, T. I.
    Kotova, E. A.
    Zaspa, A. A.
    Chernyak, B. V.
    Skulachev, V. P.
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 2008, 222 (03) : 141 - 149
  • [3] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
    Antonenko, Y. N.
    Avetisyan, A. V.
    Bakeeva, L. E.
    Chernyak, B. V.
    Chertkov, V. A.
    Domnina, L. V.
    Ivanova, O. Yu.
    Izyumov, D. S.
    Khailova, L. S.
    Klishin, S. S.
    Korshunova, G. A.
    Lyamzaev, K. G.
    Muntyan, M. S.
    Nepryakhina, O. K.
    Pashkovskaya, A. A.
    Pletjushkina, O. Yu.
    Pustovidko, A. V.
    Roginsky, V. A.
    Rokitskaya, T. I.
    Ruuge, E. K.
    Saprunova, V. B.
    Severina, I. I.
    Simonyan, R. A.
    Skulachev, I. V.
    Skulachev, M. V.
    Sumbatyan, N. V.
    Sviryaeva, I. V.
    Tashlitsky, V. N.
    Vassiliev, J. M.
    Vyssokikh, M. Yu.
    Yaguzhinsky, L. S.
    Zamyatnin, A. A., Jr.
    Skulachev, V. P.
    [J]. BIOCHEMISTRY-MOSCOW, 2008, 73 (12) : 1273 - 1287
  • [4] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)
    Bakeeva, L. E.
    Barskov, I. V.
    Egorov, M. V.
    Isaev, N. K.
    Kapelko, V. I.
    Kazachenko, A. V.
    Kirpatovsky, V. I.
    Kozlovsky, S. V.
    Lakomkin, V. L.
    Levina, S. B.
    Pisarenko, O. I.
    Plotnikov, E. Y.
    Saprunova, V. B.
    Serebryakova, L. I.
    Skulachev, M. V.
    Stelmashook, E. V.
    Studneva, I. M.
    Tskitishvili, O. V.
    Vasilyeva, A. K.
    Victorov, I. V.
    Zorov, D. B.
    Skulachev, V. P.
    [J]. BIOCHEMISTRY-MOSCOW, 2008, 73 (12) : 1288 - 1299
  • [5] Behl C, 2005, SUB CELL BIOCHEM, V38, P65
  • [6] beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
    Bruce, AJ
    Malfroy, B
    Baudry, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) : 2312 - 2316
  • [7] Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists
    Butterfield, D. Allan
    Griffin, Sue
    Munch, Gerald
    Pasinetti, Giulio Maria
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2002, 4 (03) : 193 - 201
  • [8] Cadenas Enrique, 2004, Molecular Aspects of Medicine, V25, P17, DOI 10.1016/j.mam.2004.02.005
  • [9] Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
    Du, Heng
    Guo, Lan
    Fang, Fang
    Chen, Doris
    Sosunov, Alexander A.
    McKhann, Guy M.
    Yan, Yilin
    Wang, Chunyu
    Zhang, Hong
    Molkentin, Jeffery D.
    Gunn-Moore, Frank J.
    Vonsattel, Jean Paul
    Arancio, Ottavio
    Chen, John Xi
    Du Yan, Shi
    [J]. NATURE MEDICINE, 2008, 14 (10) : 1097 - 1105
  • [10] Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition
    Dumont, Magali
    Ho, Daniel J.
    Calingasan, Noel Y.
    Xu, Hui
    Gibson, Gary
    Beal, M. Flint
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2009, 47 (07) : 1019 - 1027
123