Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids

被引：22

作者：

Zhou, Zhu-Gui ^{[1
]}

Li, Dong-Dong ^{[2
]}

Chen, Ying ^{[3
]}

Chen, Xi ^{[1
]}

Man, Ruo-Jun ^{[4
]}

机构：

[1] Guangxi Acad Agr Sci, Agrofood Sci & Technol Res Inst, Guangxi Key Lab Fruits & Vegetables Storage Proc, Nanning 530007, Peoples R China

[2] Nanjing Forestry Univ, Coll Chem Engn, 159 Long Pan Rd, Nanjing 210037, Peoples R China

[3] Guangxi Univ Nationalities, Nanning 530006, Peoples R China

[4] Guangxi Minzu Univ, Coll Chem & Chem Engn, Guangxi Key Lab Polysaccharide Mat & Modificat, Nanning 530006, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 07期

关键词：

Flavonoids; Structural modification; Drug design; Anti-tumor activity; Mechanisms; Apoptosis; CELL-CYCLE ARREST; PROSTATE-CANCER CELLS; LUNG-CANCER; IN-VITRO; GROWTH-FACTOR; ELLAGIC ACID; ANTIOXIDANT PROPERTIES; APOPTOSIS INDUCTION; BIOLOGICAL-ACTIVITY; DIETARY FLAVONOIDS;

D O I：

10.2174/1568026622666220308162049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Flavonoids are secondary metabolites of plants. In general,most flavonoids are combined with glucosides and have extremely complex molecular structures. In nature, these flavonoids have a variety of biological activities, such as anti-oxidation,anti-virus, anti-tumor, scavenging free radicals, etc.; however,due to poor solubility and stability of flavonoids,their bioavailability is limited. The drug design method is used to modify the structure of flavonoids to give them special properties. At present, flavonoids have shown broad application prospects in treating tumors, inhibiting proliferation, migration, invasion, angiogenesis, and multi-drug resistance of tumors and have become a research hotspot.

引用

页码：561 / 577

页数：17

共 186 条

[21] Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: Role of MAPK- and JAK/STAT-signaling [J].

Choi, Jung-Suk ;

Choi, Yean-Jung ;

Shin, Sung-Yong ;

Li, Jing ;

Kang, Sang-Wook ;

Bae, Ji-Young ;

Kim, Dong Shoo ;

Ji, Geun-Eog ;

Kang, Jung-Sook ;

Kang, Young-Hee .

JOURNAL OF NUTRITION, 2008, 138 (06) :983-990

[22] Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells [J].

Cordero-Herrera, Isabel ;

Angeles Martin, Maria ;

Goya, Luis ;

Ramos, Sonia .

FOOD AND CHEMICAL TOXICOLOGY, 2014, 64 :10-19

[23] Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents [J].

Cruz, Ines ;

Puthongking, Ploenthip ;

Cravo, Sara ;

Palmeira, Andreia ;

Cidade, Honorina ;

Pinto, Madalena ;

Sousa, Emilia .

JOURNAL OF CHEMISTRY, 2017, 2017

[24]

Cui JH, 2019, CURR MED CHEM, V26, P4799, DOI [10.2174/0929867325666181001115225, 10.2174/0929807325666181001115225]

[25] The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity [J].

da Silva, Alessandra Bispo ;

Cerqueira Coelho, Paulo Lucas ;

Oliveira, Mona das Neves ;

Oliveira, Joana Luz ;

Oliveira Amparo, Jessika Alves ;

da Silva, Karina Costa ;

Pereira Soares, Janaina Ribeiro ;

Seara Pitanga, Bruno Penas ;

Souza, Cleide dos Santos ;

de Faria Lopes, Giselle Pinto ;

Amaral da Silva, Victor Diogenes ;

Dias Costa, Maria de Fatima ;

Junier, Marie Pierre ;

Chneiweiss, Herve ;

Moura-Neto, Vivaldo ;

Costa, Silvia Lima .

BRAIN BEHAVIOR AND IMMUNITY, 2020, 85 :170-185

[26] Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues [J].

Das, Sreeparna ;

Mitra, Indrani ;

Batuta, Shaikh ;

Alam, Md. Niharul ;

Roy, Kunal ;

Begum, Naznin Ara .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (21) :5050-5054

[27]

de Dicastillo C.L., 2012, PACKAG TECHNOL SCI, V25, P246

[28] The Acetate Pathway Supports Flavonoid and Lipid Biosynthesis in Arabidopsis [J].

de Souza, Leonardo Perez ;

Garbowicz, Karolina ;

Brotman, Yariv ;

Tohge, Takayuki ;

Fernie, Alisdair R. .

PLANT PHYSIOLOGY, 2020, 182 (02) :857-869

[29] Biological activity of natural flavonoids as impacted by protein flexibility: an example of flavanones [J].

Ding, Fei ;

Peng, Wei .

MOLECULAR BIOSYSTEMS, 2015, 11 (04) :1119-1133

[30] Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation [J].

Duo, Jian ;

Ying, Guo-Guang ;

Wang, Guo-Wen ;

Zhang, Li .

MOLECULAR MEDICINE REPORTS, 2012, 5 (06) :1453-1456

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