Participation of galactosylceramide and sulfatide in glycosynapses between oligodendrocyte or myelin membranes

被引：43

作者：

Boggs, Joan M. ^{[1
,2
]}

Gao, Wen ^{[1
]}

Zhao, Jingsha ^{[3
]}

Park, Hyun-Joo ^{[1
]}

Liu, Yuanfang ^{[1
]}

Basu, Amit ^{[2
]}

机构：

[1] Hosp Sick Children, Res Inst, Mol Struct & Funct Program, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON M5G 1L5, Canada

[3] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

基金：

美国国家科学基金会;

关键词：

Glycoconjugate; Lipid raft; Signaling; Cytoskeleton; Silica nanoparticle; Glycosphingolipid; CARBOHYDRATE-CARBOHYDRATE INTERACTION; BASIC-PROTEIN; CONTAINING LIPOSOMES; MONOCLONAL-ANTIBODY; CEREBROSIDE SULFATE; DIFFERENTIATION; CELLS; GLYCOPROTEIN; CYTOSKELETON; EXPRESSION;

D O I：

10.1016/j.febslet.2009.11.074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two major glycosphingolipids of myelin, galactosylceramide (GalC) and sulfatide (SGC), interact with each other by trans carbohydrate-carbohydrate interactions. They face each other in the apposed extracellular surfaces of the multilayered myelin sheath produced by oligodendrocytes (OLs). Multivalent galactose and sulfated galactose, in the form of GalC/SGC-containing liposomes or silica nanoparticles conjugated to galactose and galactose-3-sulfate, interact with GalC and SGC in the membrane sheets of OLs in culture. This stimulus results in transmembrane signaling, loss of the cytoskeleton and clustering of membrane domains, suggesting that GalC and SGC could participate in glycosynapses between apposed OL membranes or extracellular surfaces of mature myelin. Such glycosynapses may be important for myelination and/or myelin function. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1771 / 1778

页数：8

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