Cell signaling pathways as molecular targets to eliminate AML stem cells

被引：37
作者：
Rodrigues, Ana Carolina B. da C. [1 ]
Costa, Rafaela G. A. [1 ]
Silva, Suellen L. R. [1 ]
Dias, Ingrid R. S. B. [1 ]
Dias, Rosane B. [1 ]
Bezerra, Daniel P. [1 ]
机构：
[1] Oswaldo Cruz Fdn IGM FIOCRUZ BA, Goncalo Moniz Inst, BR-40296710 Salvador, BA, Brazil
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 160卷
关键词：
Acute myeloid leukemia; Cell signaling; Leukemic stem cells; Target therapy; ACUTE MYELOID-LEUKEMIA; NF-KAPPA-B; ACTIVATED-RECEPTOR-GAMMA; HISTONE DEACETYLASE INHIBITOR; POTENTIAL THERAPEUTIC TARGET; PROTEIN-KINASE CK2; SELF-RENEWAL; MYELODYSPLASTIC SYNDROME; HEDGEHOG PATHWAY; GENE-EXPRESSION;
D O I：
10.1016/j.critrevonc.2021.103277
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-kappa B, Wnt/beta-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
引用
收藏
页数：22
相关论文
共 271 条
[1]   Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs [J].
Adams, Drew J. ;
Dai, Mingji ;
Pellegrino, Giovanni ;
Wagner, Bridget K. ;
Stern, Andrew M. ;
Shamji, Alykhan F. ;
Schreiber, Stuart L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (38) :15115-15120
[2]   Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia [J].
Akalin, Altuna ;
Garrett-Bakelman, Francine E. ;
Kormaksson, Matthias ;
Busuttil, Jennifer ;
Zhang, Lu ;
Khrebtukova, Irina ;
Milne, Thomas A. ;
Huang, Yongsheng ;
Biswas, Debabrata ;
Hess, Jay L. ;
Allis, C. David ;
Roeder, Robert G. ;
Valk, Peter J. M. ;
Lowenberg, Bob ;
Delwel, Ruud ;
Fernandez, Hugo F. ;
Paietta, Elisabeth ;
Tallman, Martin S. ;
Schroth, Gary P. ;
Mason, Christopher E. ;
Melnick, Ari ;
Figueroa, Maria E. .
PLOS GENETICS, 2012, 8 (06)
[3]   MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC [J].
Alam, Maroof ;
Ahmad, Rehan ;
Rajabi, Hasan ;
Kufe, Donald .
MOLECULAR CANCER RESEARCH, 2015, 13 (03) :449-460
[4]   The paradoxical functions of EGFR during breast cancer progression [J].
Ali, Remah ;
Wendt, Michael K. .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2017, 2
[5]  
Altaba ARI, 2002, NAT REV NEUROSCI, V3, P24
[6]  
[Anonymous], 2020, CANC FACTS FIGURES 2
[7]   Selective regulation of Notch ligands during angiogenesis is mediated by vimentin [J].
Antfolk, Daniel ;
Sjoqvist, Marika ;
Cheng, Fang ;
Isoniemi, Kimmo ;
Duran, Camille L. ;
Rivero-Muller, Adolfo ;
Antila, Christian ;
Niemi, Rasmus ;
Landor, Sebastian ;
Bouten, Carlijn V. C. ;
Bayless, Kayla J. ;
Eriksson, John E. ;
Sahlgren, Cecilia M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (23) :E4574-E4581
[8]   The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].
Backer, Jonathan M. .
BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17
[9]   Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B [J].
Bae, SS ;
Cho, H ;
Mu, J ;
Birnbaum, MJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :49530-49536
[10]   Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt [J].
Bai, Dong ;
Ueno, Lynn ;
Vogt, Peter K. .
INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (12) :2863-2870
12345678910