Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide

被引：52
作者：
Alazet, Sebastien [1 ,2 ]
Billard, Thierry [1 ,2 ]
机构：
[1] Univ Lyon 1, CNRS, Univ Lyon, Inst Chem & Biochem,ICBMS,UMR 5246, F-69622 Lyon, France
[2] Groupement Hospitalier Est, CERMEP, F-69003 Lyon, France
来源：
SYNLETT | 2015年 / 26卷 / 01期
关键词：
trifluoromethylthiolation; fluorine; arenes; heterocycles; trifluoromethanesulfenamide; MEDICINAL CHEMISTRY; FLUORINE; PREDICTION;
D O I：
10.1055/s-0034-1379501
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Direct trifluoromethylthiolation of various aromatic and heteroaromatic compounds, variously substituted, can be performed with the second generation of trifluoromethanesulfenamide via a 'Friedel-Crafts-like reaction'. This reaction requires mild conditions with a catalytic amount of protic or Lewis acid. Good results have been obtained, even with aromatic compounds bearing deactivating substituents.
引用
收藏
页码：76 / 78
页数：3
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