Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide

被引：52

作者：

Alazet, Sebastien ^{[1
,2
]}

Billard, Thierry ^{[1
,2
]}

机构：

[1] Univ Lyon 1, CNRS, Univ Lyon, Inst Chem & Biochem,ICBMS,UMR 5246, F-69622 Lyon, France

[2] Groupement Hospitalier Est, CERMEP, F-69003 Lyon, France

来源：

SYNLETT | 2015年 / 26卷 / 01期

关键词：

trifluoromethylthiolation; fluorine; arenes; heterocycles; trifluoromethanesulfenamide; MEDICINAL CHEMISTRY; FLUORINE; PREDICTION;

D O I：

10.1055/s-0034-1379501

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct trifluoromethylthiolation of various aromatic and heteroaromatic compounds, variously substituted, can be performed with the second generation of trifluoromethanesulfenamide via a 'Friedel-Crafts-like reaction'. This reaction requires mild conditions with a catalytic amount of protic or Lewis acid. Good results have been obtained, even with aromatic compounds bearing deactivating substituents.

引用

页码：76 / 78

页数：3

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