Extracellular vesicles as drug vectors for precise cancer treatment

被引：22
作者：
Cao, Xin-Hui [1 ,2 ]
Liang, Ming-Xing [1 ]
Wu, Yang [3 ]
Yang, Kai [2 ]
Tang, Jin-Hai [1 ,2 ]
Zhang, Wei [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing 210029, Peoples R China
[2] Xuzhou Med Univ, Sch Clin Med, Xuzhou 221000, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Biobank, Nanjing 210029, Peoples R China
来源：
NANOMEDICINE | 2021年 / 16卷 / 17期
基金：
中国国家自然科学基金;
关键词：
cancer therapy; drug delivery; exosomes; extracellular vesicles; nanocarriers; GROWTH-FACTOR RECEPTOR; PROTOPLAST-DERIVED NANOVESICLES; EXOSOME-MIMETIC NANOVESICLES; MESENCHYMAL STEM-CELLS; INHIBIT IN-VITRO; HEPATOCELLULAR-CARCINOMA; TARGETED DELIVERY; BERRY ANTHOCYANIDINS; SURFACE MODIFICATION; CO-DELIVERY;
D O I：
10.2217/nnm-2021-0123
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Extracellular vesicles (EVs) are nano-sized vesicle structures secreted from a variety of cells, which carry numerous biological macromolecules, participate in cell signal transduction and avoid immune system clearance. EVs have a plethora of specific signal recognition factors, and many studies have shown that they can play an important role in the precise treatment of tumors. This review aims to compile the applications of EVs as nanocarriers for antitumor drugs, gene drugs and other nanomaterials with anticancer capability. Additionally, we systematically summarize the preparation methodology and expound upon how to improve the drug loading and cancer-targeting capacity of EVs. We highlight that EV-based drug delivery has the potential to become the future of precise cancer treatment.
引用
收藏
页码：1519 / 1537
页数：19
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