Synthesis of oligosaccharide fragments of the Streptococcus pneumoniae type 14 capsular polysaccharide and their neoglycoconjugates with bovine serum albumin

被引：17

作者：

Sukhova, E. V. ^{[1
]}

Yashunsky, D. V. ^{[1
,2
]}

Tsvetkov, Yu E. ^{[1
]}

Kurbatova, E. A. ^{[3
]}

Nifantiev, N. E. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[2] Russian Acad Med Sci, VN Orekhovich Res Inst Biomed Chem, Moscow 119121, Russia

[3] Russian Acad Med Sci, II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 02期

关键词：

Streptococcus pneumoniae type 14; capsular polysaccharide; oligosaccharide fragments; synthesis; neoglycoconjugates; CHEMOENZYMATIC SYNTHESIS; REPEATING UNIT; TETRASACCHARIDE; DERIVATIVES; IMMUNOGENICITY; ANTIBODIES; CHEMISTRY; PROTEINS; SQUARATE; VACCINE;

D O I：

10.1007/s11172-014-0462-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Aminoethyl glycosides of tetra-, hexa- and octasaccharide fragments of the bacteria Streptococcus pneumoniae type 14 capsular polysaccharide were synthesized within a project directed to the development of pneumococcal conjugated vaccine based on synthetic carbohydrate ligands. Squarate method was used to obtain neoglycoconjugates of the synthesized oligosaccharides with bovine serum albumin.

引用

页码：511 / 521

页数：11

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