Microvascular Dysfunction and Cognitive Impairment

被引:129
作者
De Silva, T. Michael [1 ,2 ,3 ,4 ]
Faraci, Frank M. [1 ,2 ,3 ,5 ]
机构
[1] Univ Iowa, Carver Coll Med, Francois M Abboud Cardiovasc Ctr, Dept Internal Med, Iowa City, IA USA
[2] Univ Iowa, Carver Coll Med, Francois M Abboud Cardiovasc Ctr, Dept Pharmacol, Iowa City, IA USA
[3] Iowa City Vet Affairs Healthcare Syst, Iowa City, IA USA
[4] Monash Univ, Dept Pharmacol, Biomed Discovery Inst, 9 Ancora Imparo Way, Clayton, Vic 3168, Australia
[5] Univ Iowa, Carver Coll Med, Dept Internal Med, EMRB 340F, Iowa City, IA 52242 USA
基金
英国医学研究理事会;
关键词
Endothelium; Cerebral circulation; Microcirculation; Vascular remodeling; Hypertension; Diabetes; CEREBRAL VASCULAR DYSFUNCTION; BLOOD-BRAIN-BARRIER; SPONTANEOUSLY HYPERTENSIVE-RATS; NITRIC-OXIDE SYNTHASE; SMALL VESSEL DISEASE; ENDOTHELIUM-DEPENDENT RESPONSES; ACTIVATED RECEPTOR-GAMMA; SMOOTH-MUSCLE-CELLS; AUTOSOMAL-DOMINANT ARTERIOPATHY; AMYLOID PRECURSOR PROTEIN;
D O I
10.1007/s10571-015-0308-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral vasculature is critical for proper cognitive performance. The cerebral microvasculature is a key site of vascular resistance and a preferential target for small vessel disease. While deleterious effects of vascular risk factors on microvascular function are known, the contribution of this dysfunction to cognitive deficits is less clear. In this review, we summarize current evidence for microvascular dysfunction in brain. We highlight effects of select vascular risk factors (hypertension, diabetes, and hyperhomocysteinemia) on the pial and parenchymal circulation. Lastly, we discuss potential links between microvascular disease and cognitive function, highlighting current gaps in our understanding.
引用
收藏
页码:241 / 258
页数:18
相关论文
共 192 条
[1]   Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes [J].
Abd-Elrahman, Khaled S. ;
Walsh, Michael P. ;
Cole, William C. .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2015, 93 (03) :177-184
[2]   Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells [J].
Alexis, Jeffrey D. ;
Wang, Nadan ;
Che, Wenyi ;
Lerner-Marmarosh, Nicole ;
Sahni, Abha ;
Korshunov, Vyacheslav A. ;
Zou, Yiping ;
Ding, Bo ;
Yan, Chen ;
Berk, Bradford C. ;
Abe, Jun-ichi .
CIRCULATION RESEARCH, 2009, 104 (01) :69-78
[3]  
[Anonymous], 2014, Cerebral Small Vessel Disease
[4]  
[Anonymous], STROKE GENETICS
[5]   Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises [J].
Armulik, Annika ;
Genove, Guillem ;
Betsholtz, Christer .
DEVELOPMENTAL CELL, 2011, 21 (02) :193-215
[6]   Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats [J].
Arrick, Denise M. ;
Sharpe, Glenda M. ;
Sun, Hong ;
Mayhan, William G. .
BRAIN RESEARCH, 2008, 1209 :128-135
[7]  
Arrick DM, 2014, STUDIES DIABETES OXI, P13
[8]   Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect [J].
Ayata, Cenk ;
Shin, Hwa Kyoung ;
Dilekoez, Ergin ;
Atochin, Dmitriy N. ;
Kashiwagi, Satoshi ;
Eikermann-Haerter, Katharina ;
Huang, Paul L. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (06) :954-962
[9]   Dysfunction of mouse cerebral arteries during early aging [J].
Balbi, Matilde ;
Ghosh, Mitrajit ;
Longden, Thomas A. ;
Vega, Max Jativa ;
Gesierich, Benno ;
Hellal, Farida ;
Lourbopoulos, Athanasios ;
Nelson, Mark T. ;
Plesnila, Nikolaus .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2015, 35 (09) :1445-1453
[10]   Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase [J].
Baumbach, Gary L. ;
Didion, Sean P. ;
Faraci, Frank M. .
STROKE, 2006, 37 (07) :1850-1855