The combinatorial synthesis of bicyclic privileged structures or privileged substructures

被引:2985
作者
Horton, DA
Bourne, GT
Smythe, ML [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
[2] Univ Queensland, Protagonist Pty Ltd, Gehrmann Labs Level 7, St Lucia, Qld 4072, Australia
关键词
D O I
10.1021/cr020033s
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.
引用
收藏
页码:893 / 930
页数:38
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