Bioactive nano-metal-organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria

被引：98
作者：
Bhardwaj, Neha [1 ,2 ]
Pandey, Satish K. [1 ]
Mehta, Jyotsana [1 ,2 ]
Bhardwaj, Sanjeev K. [1 ,2 ]
Kim, Ki-Hyun [3 ]
Deep, Akash [1 ,2 ]
机构：
[1] CSIR, CSIO, Sect 30 C, Chandigarh 160030, India
[2] CSIR, CSIO, Acad Sci & Innovat Res, Sect 30 C, Chandigarh 160030, India
[3] Hanyang Univ, Dept Civil & Environm Engn, 222 Wangsimni Ro, Seoul 133791, South Korea
来源：
TOXICOLOGY RESEARCH | 2018年 / 7卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
KLEBSIELLA-PNEUMONIAE; MULTIDRUG-RESISTANCE; DRUG-DELIVERY; CYTOTOXICITY; NANOPARTICLES; ZINC; STRATEGIES; PLATFORM; IMPACT; IMMOBILIZATION;
D O I：
10.1039/c8tx00087e
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal-organic frameworks (nMOFs) - IRMOF-3, MOF-5, and Zn-BTC - were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.
引用
收藏
页码：931 / 941
页数：11
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