Patient needs and benefits of sublingual immunotherapy for grass pollen-induced allergic rhinitis: an observational study

被引：10

作者：

Klein, Toni Maria ^{[1
]}

Hadler, Meike ^{[2
]}

Augustin, Matthias ^{[1
]}

Blome, Christine ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf UKE, Inst Hlth Serv Res Dermatol & Nursing IVDP, Martinistr 52, D-20246 Hamburg, Germany

[2] Stallergenes GmbH, Carl Friedrich Gauss Str 50, D-47475 Kamp Lintfort, Germany

来源：

IMMUNOTHERAPY | 2021年 / 13卷 / 14期

关键词：

adolescents; adults; allergic rhinitis; children; grass pollen; patient-relevant benefit; patient-reported outcomes; rhinoconjunctivitis; sublingual immunotherapy; treatment goals; BURDEN; ASTHMA; PREVALENCE; EFFICACY; TABLET; IMPACT;

D O I：

10.2217/imt-2021-0161

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: Clinical efficacy of sublingual immunotherapy for grass pollen-induced allergic rhinitis (AR) needs to translate into patient benefit. Patients & methods: Patients received Oralair (Stallergenes, Antony, France) in real-life medical practice. Patient-relevant treatment benefits were measured with the AR-specific Patient Benefit Index. Subgroups were analyzed regarding distinct patient characteristics. Results: Data of 883 patients (children, adolescents, and adults) were analyzed. The highest-ranked patient needs referred to having less AR-symptoms, being able to go outdoors, and being free in the choice of leisure activities. Most patients (89.2-94.6%) attained at least minimally relevant benefit. All subgroups reported relevant benefits, with significantly higher scores in some subgroups. Conclusion: Treatment with Oralair was associated with considerable patient-relevant benefit in all age groups.

引用

页码：1193 / 1204

页数：12

共 28 条

[1] The patient benefit index: a novel approach in patient-defined outcomes measurement for skin diseases [J].

Augustin, Matthias ;

Radtke, Marc A. ;

Zschocke, Ina ;

Blome, Christine ;

Behechtnejad, Julia ;

Schaefer, Ines ;

Reusch, Michael ;

Mielke, Volker ;

Rustenbach, Stephan Jeff .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2009, 301 (08) :561-571

[2] A literature review to explore the link between treatment satisfaction and adherence, compliance, and persistence [J].

Barbosa, Carla Dias ;

Balp, Maria-Magdalena ;

Kulich, Karoly ;

Germain, Nicola ;

Rofail, Diana .

PATIENT PREFERENCE AND ADHERENCE, 2012, 6 :39-48

[3] Prevalence and rate of diagnosis of allergic rhinitis in Europe [J].

Bauchau, V ;

Durham, SR .

EUROPEAN RESPIRATORY JOURNAL, 2004, 24 (05) :758-764

[4] Relevant Patient Benefit of Sublingual Immunotherapy with Birch Pollen Allergen Extract in Allergic Rhinitis: An Open, Prospective, Non-Interventional Study [J].

Blome, Christine ;

Hadler, Meike ;

Karagiannis, Efstrathios ;

Kisch, Julia ;

Neht, Christopher ;

Kressel, Nora ;

Augustin, Matthias .

ADVANCES IN THERAPY, 2020, 37 (06) :2932-2945

[5] Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) [J].

Bousquet, J. ;

Khaltaev, N. ;

Cruz, A. A. ;

Denburg, J. ;

Fokkens, W. J. ;

Togias, A. ;

Zuberbier, T. ;

Baena-Cagnani, C. E. ;

Canonica, G. W. ;

van Weel, C. ;

Agache, I. ;

Ait-Khaled, N. ;

Bachert, C. ;

Blaiss, M. S. ;

Bonini, S. ;

Boulet, L. -P. ;

Bousquet, P. -J. ;

Camargos, P. ;

Carlsen, K. -H. ;

Chen, Y. ;

Custovic, A. ;

Dahl, R. ;

Demoly, P. ;

Douagui, H. ;

Durham, S. R. ;

van Wijk, R. Gerth ;

Kalayci, O. ;

Kaliner, M. A. ;

Kim, Y. -Y. ;

Kowalski, M. L. ;

Kuna, P. ;

Le, L. T. T. ;

Lemiere, C. ;

Li, J. ;

Lockey, R. F. ;

Mavale-Manuel, S. ;

Meltzer, E. O. ;

Mohammad, Y. ;

Mullol, J. ;

Naclerio, R. ;

Hehir, R. E. O. ;

Ohta, K. ;

Ouedraogo, S. ;

Palkonen, S. ;

Papadopoulos, N. ;

Passalacqua, G. ;

Pawankar, R. ;

Popov, T. A. ;

Rabe, K. F. ;

Rosado-Pinto, J. .

ALLERGY, 2008, 63 :8-+

[6] Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision [J].

Brozek, Jan L. ;

Bousquet, Jean ;

Agache, Ioana ;

Agarwal, Arnav ;

Bachert, Claus ;

Bosnic-Anticevich, Sinthia ;

Brignardello-Petersen, Romina ;

Canonica, G. Walter ;

Casale, Thomas ;

Chavannes, Niels H. ;

de Sousa, Jaime Correia ;

Cruz, Alvaro A. ;

Cuello-Garcia, Carlos A. ;

Demoly, Pascal ;

Dykewicz, Mark ;

Etxeandia-Ikobaltzeta, Itziar ;

Florez, Ivan D. ;

Fokkens, Wytske ;

Fonseca, Joao ;

Hellings, Peter W. ;

Klimek, Ludger ;

Kowalski, Sergio ;

Kuna, Piotr ;

Laisaar, Kaja-Triin ;

Larenas-Linnemann, Desiree E. ;

Carlsen, Karin C. Lodrup ;

Manning, Peter J. ;

Meltzer, Eli ;

Mullol, Joaquim ;

Muraro, Antonella ;

O'Hehir, Robyn ;

Ohta, Ken ;

Panzner, Petr ;

Papadopoulos, Nikolaos ;

Park, Hae-Sim ;

Passalacqua, Gianni ;

Pawankar, Ruby ;

Price, David ;

Riva, John J. ;

Roldan, Yetiani ;

Ryan, Dermot ;

Sadeghirad, Behnam ;

Samolinski, Boleslaw ;

Schmid-Grendelmeier, Peter ;

Sheikh, Aziz ;

Togias, Alkis ;

Valero, Antonio ;

Valiulis, Arunas ;

Valovirta, Erkka ;

Ventresca, Matthew .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :950-958

[7] A survey of the burden of allergic rhinitis in Europe [J].

Canonica, G. W. ;

Bousquet, J. ;

Mullol, J. ;

Scadding, G. K. ;

Virchow, J. C. .

ALLERGY, 2007, 62 :17-25

[8] Clinical efficacy of 300IR 5-grass pollen sublingual tablet in a US study: The importance of allergen-specific serum IgE [J].

Cox, Linda S. ;

Casale, Thomas B. ;

Nayak, Anjuli S. ;

Bernstein, David I. ;

Creticos, Peter S. ;

Ambroisine, Laurence ;

Melac, Michel ;

Zeldin, Robert K. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (06) :1327-+

[9] Allergenic pollen and pollen allergy in Europe [J].

D'Amato, G. ;

Cecchi, L. ;

Bonini, S. ;

Nunes, C. ;

Annesi-Maesano, I. ;

Behrendt, H. ;

Liccardi, G. ;

Popov, T. ;

van Cauwenberge, P. .

ALLERGY, 2007, 62 (09) :976-990

[10] Management of the polyallergic patient with allergy immunotherapy: a practice-based approach [J].

Demoly, Pascal ;

Passalacqua, Giovanni ;

Pfaar, Oliver ;

Sastre, Joaquin ;

Wahn, Ulrich .

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2016, 12

← 1 2 3 →