Natural recombinant between equine herpesviruses 1 and 4 in the ICP4 gene

被引：33

作者：

Pagamjav, O

Sakata, T

Matsumura, T

Yamaguchi, T

Fukushi, H

机构：

[1] Gifu Univ, Fac Appl Biol Sci, Lab Vet Microbiol, Gifu 5011193, Japan

[2] Gifu Univ, Fac Appl Biol Sci, Dept Appl Vet Sci, United Grad Sch Vet Sci, Gifu 5011193, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2005年 / 49卷 / 02期

关键词：

recombination; ICP4; EHV-1; EHV-4;

D O I：

10.1111/j.1348-0421.2005.tb03716.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Equine herpesvirus 1 (EHV-1) is a pathogen causing rhinopneumonia in young horses, abortion in mares, and myeloencephalitis in adult horses. Two types, EHV-1 P and EHV-1 B, have recently been dominant among 16 electropherotypes. EHV-1 P and EHV-1 B viruses were compared by long and accurate polymerase chain reaction (LA-PCR) and restriction fragment length polymorphism (RFLP) analysis. Differences in restriction sites were found to be focused in ORF64, which encodes the infected cell protein 4 (ICP4), and downstream of the ICP4 gene. The 3'-end and downstream of ICP4 gene of EHV-1 B were found to be replaced by the corresponding region of EHV-4, indicating that EHV-1 B is a naturally occurring recombinant virus between progenitors of EHV-1 P and EHV-4. This is the first report showing a natural interspecies recombinant in alphaherpesviruses.

引用

页码：167 / 179

页数：13

共 39 条

[1]

Allen G P, 1986, Prog Vet Microbiol Immunol, V2, P78

[2]

ALLEN GP, 1983, AM J VET RES, V44, P263

[3]

ALLEN GP, 1985, AM J VET RES, V46, P138

[4] Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription [J].