Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles

被引：37

作者：

Mandour, Adel H. ^{[1
]}

El-Sawy, Eslam R. ^{[1
]}

Shaker, Kamel H. ^{[2
]}

Mustafa, Mohamed A. ^{[3
]}

机构：

[1] Natl Res Ctr, Chem Dept Nat Cpds, Giza, Egypt

[2] Univ Bayreuth, Organ Chem NWII, Bayreuth, Germany

[3] Egypt Pharmacist Co, Res Unit, Cairo, Egypt

来源：

ACTA PHARMACEUTICA | 2010年 / 60卷 / 01期

关键词：

indole-3-carboxaldehyde; anti-inflammatory activity; anticonvulsant activity; analgesic activity;

D O I：

10.2478/v10007-010-0009-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

引用

页码：73 / 88

页数：16

共 17 条

[1] SYNTHESIS OF INDAZOLES USING POLYPHOSPHORIC ACID .1. [J].