Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus CICC40205 mutant

被引：45

作者：

Wu, Xuefeng ^{[1
,4
]}

Liu, Qing ^{[1
]}

Deng, Yongdong ^{[1
]}

Li, Jinghong ^{[2
]}

Chen, Xiaoju ^{[3
]}

Gu, Yongzhong ^{[1
]}

Lv, Xijun ^{[1
]}

Zheng, Zhi ^{[1
,4
]}

Jiang, Shaotong ^{[1
,4
]}

Li, Xingjiang ^{[1
,4
]}

机构：

[1] Hefei Univ Technol, Sch Food Sci & Engn, 193 Tunxi Rd, Hefei 230009, Anhui, Peoples R China

[2] China Rural Technol Dev Ctr, Beijing 100045, Peoples R China

[3] Chaohu Univ, Coll Chem & Mat Engn, Hefei 238000, Anhui, Peoples R China

[4] Key Lab Agr Prod Proc Anhui Prov, Hefei 230009, Anhui, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2017年 / 241卷

基金：

中国国家自然科学基金;

关键词：

Wheat bran; Aspergillus terreus CICC40205; Itaconic acid; Mutagenic breeding; Metabolic flux analysis; FLUX ANALYSIS; DEHYDROGENASE; BIOSYNTHESIS; FERMENTATION; PATHWAY; BIOMASS; STARCH; XYLOSE; NIGER;

D O I：

10.1016/j.biortech.2017.05.080

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

The replacement of the carbon source in the microbial production of itaconic acid (IA) with economic alternatives has attracted significant attention. In this study, an Aspergillus terreus CICC40205 mutant was used to increase the IA titer and decrease the citric acid titer in the wheat bran hydrolysate compared with the parental strain. The results showed that the IA titer was increased by 33.4%, whereas the citric acid titer was decreased by 75.8%, and were in accordance with those of the improved pathway of cometabolism of glucose and xylose according to the metabolic flux analysis. Additionally, the maximum IA titer obtained in a 7-L stirred tank was 49.65 g L-1 +/- 0.38 g L-1. Overall, A. terreus CICC40205 showed a great potential for the industrial production of IA through the biotransformation of the wheat bran hydrolysate. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：25 / 34

页数：10

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