Studies on α-alkoxyalkylation of 2-cyclohexen-1-one with cyclic acetals 1.: Pyridiniosilylation

被引：0

作者：

Wang, F ^{[1
]}

Zibuck, R ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

SYNLETT | 1998年 / 03期

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D O I：

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中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conjugate addition of pyridine to 2-cyclohexen-1-one in the presence of TMSOTf forms a mildly nucleophilic species. This nucleophile, generated in situ, undergoes Lewis acid catalyzed aldol-type reactions with cyclic acetals. Upon beta-elimination of pyridine, alpha-alkoxyalkylated enones are produced in a one-pot reaction.

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页码：245 / 246

页数：2

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