Morphogens, morphostats, microarchitecture and malignancy

被引：81
作者：
Potter, John D. [1 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期
关键词：
D O I：
10.1038/nrc2146
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Morphogenetic fields organize tissue morphology in the embryo. By analogy, morphostatic fields maintain normal cell behaviour and normal tissue microarchitecture in the adult. The most prominent feature of cancer is the disruption of tissue microarchitecture. Cancer occurs much more frequently when morphostatic influences fail (metaplasia) or at the junction of two different morphostatic fields. This Review will describe what we know about morphostats and morphostasis, discuss the evidence for the role of disruption of morphostasis in malignancy, and address some testable hypotheses.
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收藏
页码：464 / 474
页数：11
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