COVID-19 infection in patients with intestinal failure: UK experience

被引：4

作者：

Allan, P. J. ^{[1
]}

Ambrose, T. ^{[1
]}

Mountford, C. ^{[2
]}

Bond, A. ^{[3
]}

Donnellan, C. ^{[4
]}

Boyle, R. ^{[5
]}

Calvert, C. ^{[6
]}

Cernat, E. ^{[7
]}

Clarke, E. ^{[8
]}

Cooper, S. C. ^{[9
]}

Donnelly, S. ^{[10
]}

Evans, B. ^{[11
]}

Glynn, M. ^{[12
]}

Hewett, R. ^{[13
]}

Holohan, A. S. ^{[14
]}

Leitch, E. F. ^{[15
]}

Louis-Auguste, J. ^{[16
]}

Mehta, S. ^{[17
]}

Naik, S. ^{[18
]}

Nightingale, J. ^{[19
]}

Rafferty, G. ^{[20
]}

Rodrigues, A. ^{[21
]}

Sharkey, L. ^{[22
]}

Small, M. ^{[10
]}

Teubner, A. ^{[23
]}

Urs, A. ^{[24
]}

Wyer, N. ^{[25
]}

Lal, S. ^{[23
,26
,27
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Translat Gastroenterol Unit, NIHR Oxford Biomed Res Ctr, Oxford, England

[2] Freeman Rd Hosp, Dept Gastroenterol, Newcastle Upon Tyne, Tyne & Wear, England

[3] Royal Liverpool & Broadgreen Hosp, Dept Gastroenterol, Liverpool, Merseyside, England

[4] St James Hosp, St James & Leeds Gastroenterol Inst, Leeds, W Yorkshire, England

[5] Aberdeen Royal Infirm, Dept Biochem, Aberdeen, Scotland

[6] Royal Devon & Exeter Hosp, Dept Gastroenterol, Exeter, Devon, England

[7] Leeds Gen Infirm, Dept Paediat Gastroenterol, Leeds, W Yorkshire, England

[8] Southampton Univ Hosp, Dept Gastroenterol, Southampton, Hants, England

[9] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, GI Med, Birmingham, W Midlands, England

[10] St Marks Hosp, Leonard Jones Intestinal Rehabil Unit, Harrow, Middx, England

[11] Bristol Royal Infirm & Gen Hosp, Dept Gastroenterol, Bristol, Avon, England

[12] Royal London Hosp, Ctr Digest Dis, London, England

[13] Univ Wales Hosp, Dept Gastroenterol, Cardiff, Wales

[14] Leicester Royal Infirm, Nutr, Leicester, Leics, England

[15] Glasgow Royal Infirm, Intestinal Failure Surg, Glasgow, Lanark, Scotland

[16] St Georges, Dept Gastroenterol, London, England

[17] Univ Coll London Hosp, Intestinal Failure Unit, London, England

[18] Royal London Childrens Hosp, Dept Paediat Gastroenterol, London, England

[19] St Marks Hosp, London, England

[20] Belfast City Hosp, Dept Gastroenterol, Belfast, Antrim, North Ireland

[21] Oxford Univ Hosp NHS Fdn Trust, Dept Paediat Gastroenterol, Oxford, England

[22] Cambridge Univ Hosp, Intestinal Failure & Transplant, Cambridge, England

[23] Salford Royal Hosp, Intestinal Failure Unit, Salford, Lancs, England

[24] Sheffield Childrens Hosp, Paediat Gastroenterol, Sheffield, S Yorkshire, England

[25] Univ Hosp Coventry andWarwickshire, Intestinal Failure & Nutr Support, Coventry, W Midlands, England

[26] Univ Manchester, Div Diabet Endocrinol & Gastroenterol, Sch Med Sci, Fac Biol Med & Hlth, Manchester, Lancs, England

[27] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

来源：

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 2021年 / 45卷 / 06期

关键词：

COVID-19; home parenteral nutrition; intestinal failure; outcome;

D O I：

10.1002/jpen.2087

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background The direct effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with intestinal failure (IF) has not been described. Methods We conducted a nationwide study of UK IF centers to evaluate the infection rates, presentations, and outcomes in patients with types 2 and 3 IF. Results A total of 45 patients with IF contracted COVID-19 between March and August 2020; this included 26 of 2191 (1.2%) home parenteral nutrition (HPN)-dependent adults and 19 of 298 (6.4%) adults hospitalized with type 2 IF. The proportion of patients receiving nursing care for HPN administration was higher in those with community-acquired COVID-19 (66.7%) than the proportion in the entire HPN cohort (26.1%; P < .01). Two HPN-dependent and 1 hospitalized patient with type 2 IF died as a direct consequence of the virus (6.7% of 45 patients with types 2 or 3 infected). Conclusion This is the first study to describe the outcomes of COVID-19 in a large cohort of patients requiring long-term PN. Methods to reduce hospital and community nosocomial spread would likely be beneficial.

引用

页码：1369 / 1375

页数：7

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