Engineered Cationic Antimicrobial Peptides To Overcome Multidrug Resistance by ESKAPE Pathogens

被引：104

作者：

Deslouches, Berthony ^{[1
,2
]}

Steckbeck, Jonathan D. ^{[1
,2
]}

Craigo, Jodi K. ^{[1
,2
]}

Doi, Yohei ^{[3
]}

Burns, Jane L. ^{[4
]}

Montelaro, Ronald C. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Ctr Vaccine Res, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Med, Dept Med, Div Infect Dis, Pittsburgh, PA 15213 USA

[4] Seattle Childrens Res Inst, Div Pediat Infect Dis, Seattle, WA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 02期

关键词：

ANTIBIOTIC-PROPHYLAXIS; PSEUDOMONAS-AERUGINOSA; COLISTIN-RESISTANT; NO ESKAPE; TRYPTOPHAN; GUIDELINE; INFECTION; PARADIGM; BACTERIA; SURGERY;

D O I：

10.1128/AAC.03937-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.

引用

页码：1329 / 1333

页数：5

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