Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

被引：49

作者：

Kim, Mi Jeong

Choi, Soo Jung

Lim, Seung-Taik

Kim, Hye Kyung

Heo, Ho Jin

Kim, Eun-Ki

Jun, Woo Jin

Cho, Hong Yon

Kim, Young Jun

Shin, Dong-Hoon ^{[1
]}

机构：

[1] Korea Univ, Dept Food & Biotechnol, Seoul 136701, South Korea

[2] Korea Univ, Grad Sch Life Sci & Biotechnol, Seoul 136701, South Korea

[3] Hanseo Univ, Dept Food & Biotechnol, Chungnam 356706, South Korea

[4] Jeonnam Innovat Agcy, Jeonnam 534700, South Korea

[5] Inha Univ, Dept Biol Engn, Inchon 402751, South Korea

[6] Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 04期

关键词：

choline acetyltransferase; cognitive function; ferulic acid (4-hydroxy-3-methoxycinnamic acid); trimethyltin;

D O I：

10.1271/bbb.60564

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

引用

页码：1063 / 1068

页数：6

共 27 条

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