Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite

被引：9

作者：

Al-Qubaisi, Mothanna Sadiq ^{[1
]}

Al-Abboodi, Ashwaq Shakir ^{[2
]}

Alhassan, Fatah H. ^{[3
]}

Hussein-Al-Ali, Samer ^{[4
]}

Flaifel, Moayad Husein ^{[5
,6
]}

Eid, Eltayeb E. M. ^{[7
]}

Alshwyeh, Hussah Abdullah ^{[6
,8
]}

Hussein, Mohd Zobir ^{[9
]}

Alnasser, Sulaiman Mohammed ^{[10
]}

Saeed, Mohammed Ibrahim

Rasedee, Abdullah ^{[1
,11
,14
]}

Ibrahim, Wisam Nabeel ^{[12
,13
]}

机构：

[1] Univ Putra Malaysia, Inst Biosci, Upm Serdang 43400, Selangor, Malaysia

[2] Univ Al Qadisiyah, Fac Dent, Basic Sci Branch, Al Diwaniyah, Iraq

[3] Alkamel Univ Jeddah, Coll Sci & Arts, Dept Appl Chem & Technol, Jeddah 21589, Saudi Arabia

[4] Isra Univ, Fac Pharm, Amman 11622, Jordan

[5] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Phys, Dammam 31441, Saudi Arabia

[6] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Basic & Appl Sci Res Ctr, Dammam 31441, Saudi Arabia

[7] Qassim Univ, Unaizah Coll Pharm, Dept Pharmaceut Chem & Pharmacognosy, Buraydah, Saudi Arabia

[8] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Biol, Dammam 31441, Saudi Arabia

[9] Univ Putra Malaysia, Fac Sci, Dept Chem, Upm Serdang 43400, Selangor, Malaysia

[10] Qassim Univ, Unaizah Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia

[11] Univ Putra Malaysia, Fac Vet Med, Dept Vet Pathol & Microbiol, Upm Serdang 43400, Selangor, Malaysia

[12] Qatar Univ, Coll Hlth Sci, Dept Biomed Sci, QU Hlth, Doha, Qatar

[13] Qatar Univ, Biomed & Pharmaceut Res Unit, QU Hlth, Doha, Qatar

[14] Natl Ribat Univ, Fac Med Lab Sci, Dept Vet Lab Diag, Khartoum 11111, Selangor, Sudan

来源：

SAUDI PHARMACEUTICAL JOURNAL | 2022年 / 30卷 / 04期

关键词：

Thymoquinone; Nanocomposite; High-pressure homogenizer; Drug release; RAW; 264.7; cells; Inflammatory mediators; NITRIC-OXIDE; PROSTAGLANDIN E-2; NIGELLA-SATIVA; RAW; 264.7; INFLAMMATION; COMPLEX; HEALTH; GROWTH; FORMULATIONS; ANTIOXIDANT;

D O I：

10.1016/j.jsps.2022.02.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their antiinflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin E2, tumor necrosis factor -a, interleukin-6, and interleukin-1b. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable nanoparticles. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective antiinflammatory therapeutic compound. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

引用

页码：347 / 358

页数：12

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