Chemical Constituents from the Root Bark of Calophyllum inophyllum

被引：0

作者：

Sichaem, Jirapast ^{[1
]}

Tip-pyang, Santi ^{[2
]}

Siripong, Pongpun ^{[3
]}

机构：

[1] Thammasat Univ Lampang Ctr, Fac Sci & Technol, Dept Chem, Lampang 52190, Thailand

[2] Chulalongkorn Univ, Dept Chem, Ctr Excellence Nat Prod Chem, Fac Sci, Bangkok 10330, Thailand

[3] Natl Canc Inst, Res Div, Nat Prod Res Sect, Bangkok 10400, Thailand

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 06期

关键词：

Calophyllum inophyllum; Guttiferae; Caloinophyllin B; Chromanone derivative; Cytotoxicity; WALSURA-TRICHOSTEMON; STEM BARK; XANTHONES; LEAVES; PYRANOXANTHONE; DERIVATIVES; INHIBITORS; VENULOSUM; COUMARINS; SOULATTRI;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new chromanone derivative, namely caloinophyllin B (1), along with seventeen known compounds 2-18 were isolated from the root bark of Calophyllum inophyllum. The structures of all isolated compounds (1-18) were determined by spectroscopic methods as well as comparison with previous reports in the literature. To the best of our knowledge, compounds 1, 3, 6, 8, 11-14 and 16 were isolated from this plant for the first time. Moreover, all isolated compounds (1-18) were evaluated for their cytotoxicity against KB and Hela S-3 cell lines. Compound 8 exhibited moderate activity toward KB and Hela S-3cells with the IC50 values of 25.8 and 18.1 mu M, respectively.

引用

页码：727 / 729

页数：3

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