Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals

被引：66
作者：
Zhao, Yiqiang [1 ]
Du, Zhuo [1 ]
Li, Ning [1 ]
机构：
[1] China Agr Univ, State Key Lab Agrobiotechnol, Beijing 10094, Peoples R China
来源：
FEBS LETTERS | 2007年 / 581卷 / 10期
基金：
中国国家自然科学基金;
关键词：
G-quadruplex; G4; DNA; transcription; transcription start site; transcriptional regulatory region; warm-blooded animal;
D O I：
10.1016/j.febslet.2007.04.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A comprehensive analysis of potential G4 DNA motifs (G4Ms) in genomic regions flanking transcription start sites (TSS) was performed across 13 animal species. We found that G4Ms are significantly enriched in the transcriptional regulatory regions (TRRs) of warm-blooded animals. Further analysis of human genes in different temporal groups reveals that the enrichment is not specific to genes found only in warm-blooded species but instead exist in a wide range of genes. Our findings therefore suggest that the high prevalence of G4Ms in TRRs is extensively selected in warm-blooded animals, supporting the hypothesis that G4Ms are involved in the regulation of gene transcription. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1951 / 1956
页数：6
相关论文
共 30 条
  • [11] Loop-length-dependent folding of G-quadruplexes
    Hazel, P
    Huppert, J
    Balasubramanian, S
    Neidle, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (50) : 16405 - 16415
  • [12] Prevalence of quadruplexes in the human genome
    Huppert, JL
    Balasubramanian, S
    [J]. NUCLEIC ACIDS RESEARCH, 2005, 33 (09) : 2908 - 2916
  • [13] G-quadruplexes in promoters throughout the human genome
    Huppert, Julian L.
    Balasubramanian, Shankar
    [J]. NUCLEIC ACIDS RESEARCH, 2007, 35 (02) : 406 - 413
  • [14] The UCSC Table Browser data retrieval tool
    Karolchik, D
    Hinrichs, AS
    Furey, TS
    Roskin, KM
    Sugnet, CW
    Haussler, D
    Kent, WJ
    [J]. NUCLEIC ACIDS RESEARCH, 2004, 32 : D493 - D496
  • [15] Keniry MA, 2001, BIOPOLYMERS, V56, P123, DOI 10.1002/1097-0282(2000/2001)56:3<123::AID-BIP10010>3.0.CO
  • [16] 2-3
  • [17] Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ
    Lew, A
    Rutter, WJ
    Kennedy, GC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) : 12508 - 12512
  • [18] Dynamic roles for G4 DNA in the biology of eukaryotic cells
    Maizels, Nancy
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) : 1055 - 1059
  • [19] Comparative genomics - Difference of expression
    Nielsen, R
    [J]. NATURE, 2006, 440 (7081) : 161 - 161
  • [20] Putative DNA quadruplex formation within the human c-kit oncogene
    Rankin, S
    Reszka, AP
    Huppert, J
    Zloh, M
    Parkinson, GN
    Todd, AK
    Ladame, S
    Balasubramanian, S
    Neidle, S
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (30) : 10584 - 10589
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