Retrobulbar Injection of Amphotericin B for Orbital Mucormycosis

被引：45

作者：

Hirabayashi, Kristin E. ^{[1
]}

Kalin-Hajdu, Evan ^{[1
]}

Brodie, Frank L. ^{[1
]}

Kersten, Robert C. ^{[1
]}

Russell, Matthew S. ^{[2
]}

Vagefi, M. Reza ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Ophthalmol, 10 Koret Way,Rm 201, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA

来源：

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY | 2017年 / 33卷 / 04期

关键词：

CRYPTOCOCCAL MENINGITIS; ASPERGILLUS; MANAGEMENT; INFECTION; TOXICITY; THERAPY;

D O I：

10.1097/IOP.0000000000000806

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A 68-year-old immunocompromised man with rhino-orbital-cerebral mucormycosis was treated with retrobulbar injections of amphotericin B deoxycholate in conjunction with intravenous antifungals and endoscopic sinus debridement. Transient episodes of orbital inflammation were noted after retrobulbar injections, but progression of orbital infection was halted and visual acuity restored with eventual hospital discharge. To the authors' knowledge, clearance of orbital mucormycosis with retrobulbar amphotericin B injections has not been previously reported. This intervention may be a viable therapeutic option in cases of orbital mucormycosis where aggressive orbital debridement is not favored and/or the burden of orbital disease is not substantial. However, physicians should be aware of the risk of transient orbital inflammation secondary to retrobulbar amphotericin B deoxycholate.

引用

页码：E94 / E97

页数：5

共 20 条

[1]

Brodie Frank L, 2016, Am J Ophthalmol Case Rep, V1, P8, DOI 10.1016/j.ajoc.2016.01.003

[2] INTRAORBITAL INJECTION OF AMPHOTERICIN-B FOR PALLIATIVE TREATMENT OF ASPERGILLUS ORBITAL ABSCESS [J].

CAHILL, KV ;

HOGAN, CD ;

KOLETAR, SL ;

GERSMAN, M .

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 1994, 10 (04) :276-277

[3] The Role of Adjunctive Therapies in the Management of Invasive Sino-Orbital Infection [J].

Colon-Acevedo, Betsy ;

Kumar, Jaya ;

Richard, Michael J. ;

Woodward, Julie A. .

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2015, 31 (05) :401-405

[4] Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity [J].

Hamill, Richard J. .

DRUGS, 2013, 73 (09) :919-934

[5] Indications for orbital exenteration in mucormycosis [J].

Hargrove, Roderick N. ;

Wesley, Ralph E. ;

Klippenstein, Kimberly A. ;

Fleming, James C. ;

Haik, Barrett G. .

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 22 (04) :286-291

[6] Amphotericin B Is Cytotoxic at Locally Delivered Concentrations [J].

Harmsen, Samuel ;

McLaren, Alex C. ;

Pauken, Christine ;

McLemore, Ryan .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2011, 469 (11) :3016-3021

[7]

Harris G J, 1989, Ophthalmic Plast Reconstr Surg, V5, P207

[8] Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro [J].

Ibrahim, AS ;

Spellberg, B ;

Avanessian, V ;

Fu, Y ;

Edwards, JE .

INFECTION AND IMMUNITY, 2005, 73 (02) :778-783

[9]

Joos ZP, 2015, OPHTHAL PLAST RECONS

[10]

Kfoury AG, 1997, CLIN TRANSPLANT, V11, P608

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