PITUITARY MACROADENOMA IN A PATIENT WITH POEMS SYNDROME IN CONJUNCTION WITH CASTLEMAN DISEASE: FIRST REPORT OF A CASE AND REVIEW OF RELATED LITERATURE

Objective: To describe file first reported case of it patient with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy. monoclonal gammopathy. and skill changes) ill conjunction with the endocrinologic manifestation Of panhypopituitarism due to it large clinically nonfunctioning pituitary adenoma Methods: We present the clinical. laboratory. and radiologic details of the case and review the relevant updated literature Results: A 48-year-old man with hypopituitarism progressive polyneuropathy presented to an outside hospital with confusion and diaphoiesis He also had diffuse lymphadenopathy. monoclonal gammopathy. and skill lesion consistent with diagnosis of POEMS syndrome Cytopathologic study of a lymph node showed findings consistent with Castleman disease A large suprasellar mass was found to be the cause of the hypopituitarism Conclusion: POEMS syndrome is it rare paraneoplastic Condition. Commonly associated with Castleman disease. that manifests with progressive distal polyneuropathy and I monoclonal plasma cell disorder. often accompanied by endocrinopathy. organomegaly, skill changes. sclerotic bone lesions. ascites, erythrocytosis, and thrombocytosis Our current patient had it]] 5 classic features of POEMS Syndrome along with Some diagnostic elements of Castleman disease. sclerotic bone lesions, and thrombocytosis TO our knowledge. this is the first known reported case of it patient whose endocrinologic manifestation of POEMS syndrome was panhypopituitarism attribute to a large clinically nonfunctioning pituitary adenoma (Endocr Pract. 20 10; 16:97-101)