Biomimetic synthesis of the nanocomposite of phosphorylatd chitosan and hydroxyapatite and its bioactivity in vitro

被引：2
作者：
Li, Quan-Li. [2 ]
Huang, Nan [2 ]
Chen, Zhiqing [3 ]
Tang, Xuyan [1 ]
机构：
[1] Anhui Med Univ, Fac Stomatol, Hefei, Peoples R China
[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat Educ Minist China, Chengdu, Peoples R China
[3] Sichuan Univ, West China Stomatol Coll, Chengdu, Peoples R China
来源：
BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷
基金：
国家高技术研究发展计划(863计划);
关键词：
phosphorylated chitosan; biomimetics; biomineralization; hydroxylapatite; osteoblast;
D O I：
10.4028/www.scientific.net/KEM.330-332.721
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Phosphorylated chitosan (PCS) was used as the template to control hydroxyapatite(HAp) growth, a novel nanocornposite composed of PCS and HAp was synthesized by biomimetic method. Calcium phosphate (Ca2+ = 60mM, Ca/P = 1.67) solution in HCl was added dropwise into PCS solution in NaOH. The precipitate was lyophilized to obtain the composite. The biocompatibility of the PCS-HAp nanocomopite was evaluated by osteoblast culture in vitro. The results showed that low crystallized HAp nanocrystals was formed on the PCS fibers and its crystal lographic c-axis were aligned preferentially parallel to the long axis direction of PCS; the composite have good biocompatibility in vitro. It is expected that the novel composite to be a potential material for bone repair.
引用
收藏
页码：721 / +
页数：2
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