Biomimetic synthesis of the nanocomposite of phosphorylatd chitosan and hydroxyapatite and its bioactivity in vitro

被引：2
作者：
Li, Quan-Li. [2 ]
Huang, Nan [2 ]
Chen, Zhiqing [3 ]
Tang, Xuyan [1 ]
机构：
[1] Anhui Med Univ, Fac Stomatol, Hefei, Peoples R China
[2] Southwest Jiaotong Univ, Key Lab Adv Technol Mat Educ Minist China, Chengdu, Peoples R China
[3] Sichuan Univ, West China Stomatol Coll, Chengdu, Peoples R China
来源：
BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷
基金：
国家高技术研究发展计划(863计划);
关键词：
phosphorylated chitosan; biomimetics; biomineralization; hydroxylapatite; osteoblast;
D O I：
10.4028/www.scientific.net/KEM.330-332.721
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Phosphorylated chitosan (PCS) was used as the template to control hydroxyapatite(HAp) growth, a novel nanocornposite composed of PCS and HAp was synthesized by biomimetic method. Calcium phosphate (Ca2+ = 60mM, Ca/P = 1.67) solution in HCl was added dropwise into PCS solution in NaOH. The precipitate was lyophilized to obtain the composite. The biocompatibility of the PCS-HAp nanocomopite was evaluated by osteoblast culture in vitro. The results showed that low crystallized HAp nanocrystals was formed on the PCS fibers and its crystal lographic c-axis were aligned preferentially parallel to the long axis direction of PCS; the composite have good biocompatibility in vitro. It is expected that the novel composite to be a potential material for bone repair.
引用
收藏
页码：721 / +
页数：2
相关论文
共 50 条
[11]   Biomimetic design of a bacterial cellulose/hydroxyapatite nanocomposite for bone healing applications [J].
Zimmermann, Kristen A. ;
LeBlanc, Jill M. ;
Sheets, Kevin T. ;
Fox, Robert W. ;
Gatenholm, Paul .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (01) :43-49
[12]   Chitosan-Hydroxyapatite Composite Obtained by Biomimetic Method as New Bone Substitute [J].
Tanase, C. E. ;
Popa, M. I. ;
Verestiuc, L. .
AT-EQUAL 2009: 2009 ECSIS SYMPOSIUM ON ADVANCED TECHNOLOGIES FOR ENHANCED QUALITY OF LIFE: LAB-RS AND ARTIPED 2009, 2009, :42-+
[13]   Fabrication and In vitro Bioactivity of Robust Hydroxyapatite Coating on Porous Titanium Implant [J].
Duan Mengna ;
Wu Xiaofeng ;
Yuan Long ;
Zhang Zhiying ;
Zhang Yan ;
Zhou Yanmin .
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2019, 35 (04) :686-692
[14]   Evaluation of bone-like apatite biomineralization on biomimetic graphene oxide/hydroxyapatite nanocomposite [J].
Hakimi, Fatemeh ;
Abroon, Maede ;
Sadighian, Somayeh ;
Ramazani, Ali .
INORGANIC CHEMISTRY COMMUNICATIONS, 2023, 149
[15]   Biomimetic synthesis of silica with chitosan-mediated morphology [J].
Leng, Boxun ;
Chen, Xin ;
Shao, Zhengzhong ;
Ming, Weihua .
SMALL, 2008, 4 (06) :755-758
[16]   Biomimetic synthesis of hydroxyapatite/bacterial cellulose nanocomposites for biomedical applications [J].
Wan, Y. Z. ;
Huang, Y. ;
Yuan, C. D. ;
Raman, S. ;
Zhu, Y. ;
Jiang, H. J. ;
He, F. ;
Gao, C. .
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2007, 27 (04) :855-864
[17]   Formation and in vitro biocompatibility of biomimetic hydroxyapatite coatings on chemically treated carbon substrates [J].
Hoppe, Alexander ;
Will, Julia ;
Detsch, Rainer ;
Boccaccini, Aldo R. ;
Greil, Peter .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (01) :193-203
[18]   Accelerated synthesis of biomimetic nano hydroxyapatite using simulated body fluid [J].
Leena, Maria ;
Rana, Deepti ;
Webster, Thomas J. ;
Ramalingam, Murugan .
MATERIALS CHEMISTRY AND PHYSICS, 2016, 180 :166-172
[19]   In vitro bioactivity of sol-gel-derived hydroxyapatite particulate nanofiber modified titanium [J].
Bajgai, Madhab Prasad ;
Parajuli, Daman Chandra ;
Park, Soo-Jin ;
Chu, Kong Hee ;
Kang, Hyung-Sub ;
Kim, Hak Yong .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (02) :685-694
[20]   Biomimetic Synthesis of Chloropupukeananin and its Congeners [J].
Suzuki T. .
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2024, 82 (04) :336-347
12345