The Bioactive Metabolites of the Mangrove Endophytic Fungus Talaromyces sp. ZH-154 Isolated from Kandelia candel (L.) Druce (vol 76, pg 185, 2010)

被引：81

作者：

Liu, Fan

Cai, Xiao-Ling

Yang, Hong

Xia, Xue-Kui

Guo, Zhi-Yong

Yuan, Jie

Li, Meng-Feng

She, Zhi-Gang

Lin, Yong-Cheng

机构：

[1] School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, No. 135, West Xingang Road

[2] Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou

[3] Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education of Guangdong, Guangzhou

来源：

PLANTA MEDICA | 2010年 / 76卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Antimicrobial activity; Cytotoxicity; Kandelia candel (L.) Druce; Metabolites; Rhizophoraceae; Talaromyces sp;

D O I：

10.1055/s-0029-1186047

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-directed fractionation of the extract of the mangrove endophytic fungus Talaromyces sp. ZH-154, which was isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae, afforded two new metabolites, 7-epiaustdiol (1) and 8-O-methylepiaustdiol (2), together with the known compounds, stemphyperylenol (3), skyrin (4), secalonic acid A (5), emodin (6), and norlichexanthone (7). Their structures were elucidated on the basis of spectroscopic evidences including CD, MS, and 1D, 2D NMR techniques. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction. All isolated compounds were evaluated for their antimicrobial and in vitro cytotoxic activities.

引用

页码：E9 / E9

页数：1