ENSURING CONTINUED PROGRESS IN BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS

被引：44

作者：

Turner, Martin R. ^{[1
]}

Benatar, Michael ^{[2
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

[2] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

来源：

MUSCLE & NERVE | 2015年 / 51卷 / 01期

基金：

英国医学研究理事会;

关键词：

biomarker; neurochemistry; neuroimaging; motor neuron disease; trial; CORTICOSPINAL TRACT DEGENERATION; NEURON DISEASE; ALS; OPPORTUNITIES; SURVIVAL; SYSTEM;

D O I：

10.1002/mus.24470

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. Replication of results, however, has been absent in all but a few cases, and the range of control samples has been limited. If progress toward clinical translation is to continue, the specific biomarker needs of ALS, which differ from those of other neuro-degenerative disorders, as well as the challenges inherent to longitudinal ALS biomarker cohorts, must be understood. Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward.

引用

页码：14 / 18

页数：5

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