Endothelin-1 stimulates NO release in the brain and causes a fall in blood pressure

被引：0

作者：

Kalinowki, L ^{[1
]}

Madajka, M ^{[1
]}

White, J ^{[1
]}

Bohr, D ^{[1
]}

Malinski, T ^{[1
]}

机构：

[1] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA

来源：

HEART DISEASE: PATHOGENESIS, DIAGNOSIS AND TREATMENT | 2003年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intracerebroventricular (ICV) infusion of endothelin-1 (ET1) causes NO release in nucleus tractus solitarius (NTS) which results in a fall in blood pressure. This action of NO probably results from the increase in intracellular sodium concentration ([Na(+)](i)) caused by NO. NO concentration increased to 400 +/- 25 nmol/L after injection of 10(-7) mol/L of ET1. In the presence of the endothelin-B receptor (ETB) selective antagonist, A-192621, the NO concentration decreased by 75% causing a slight increase in blood pressure. In our current study, direct observations confirmed that ET1-stimulated changes of NO production in NTS can influence the arterial blood pressure.

引用

页码：73 / 76

页数：4

共 12 条

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