Biotransformation of nobiletin by Aspergillus niger and the antimultagenic activity of a metabolite, 4′-hydroxy-5,6,7,8,3′-pentamethoxyflavone

被引：28

作者：

Okuno, Y ^{[1
]}

Miyazawa, M ^{[1
]}

机构：

[1] Kinki Univ, Dept Appl Chem, Fac Sci & Engn, Osaka 5778502, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np034007g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ and Trp-P-1.

引用

页码：1876 / 1878

页数：3

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