Surface markers of lymphocyte activation in pregnant asthmatics

被引：15

作者：

Bohacs, Aniko ^{[1
]}

Pallinger, Eva ^{[2
]}

Tamasi, Lilla ^{[1
]}

Rigo, Janos, Jr. ^{[3
]}

Komlosi, Zsolt ^{[1
]}

Mueller, Veronika ^{[1
]}

Dong, Yang ^{[4
]}

Magyar, Pal ^{[1
]}

Falus, Andras ^{[2
,5
]}

Losonczy, Gyoergy ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Pulmonol, H-1125 Budapest, Hungary

[2] Semmelweis Univ, Dept Genet & Cell & Immunobiol, H-1125 Budapest, Hungary

[3] Semmelweis Univ, Dept Obstet & Gynecol 1, H-1125 Budapest, Hungary

[4] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China

[5] Hungarian Acad Sci, Inflammat Biol & Immunogenom Res Grp, Budapest, Hungary

来源：

INFLAMMATION RESEARCH | 2010年 / 59卷 / 01期

基金：

匈牙利科学研究基金会;

关键词：

Asthma; Flow cytometry; Immunotolerance; Lymphocyte activation; Pregnancy; REGULATORY T-CELLS; BODY-MASS INDEX; DISEASE SEVERITY; EXPRESSION; TOLERANCE; SUBSETS; BLOOD; WOMEN; SUBPOPULATIONS; ASSOCIATION;

D O I：

10.1007/s00011-009-0070-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pregnancy-associated immunologic alterations may improve the course of asthma. Severe maternal asthma with an exacerbation impairs fetal growth. Lymphocyte activation was estimated by flow cytometry analysis of surface markers in non-pregnant healthy and mild or moderate persistent asthmatic women and healthy as well as mild or moderate persistent asthmatic, third trimester pregnant women. Compared with non-pregnant healthy subjects (n = 12) activated pools within CD4 and CD8 T cells were larger and the number of NK T cells were increased both in non-pregnant asthmatic (n = 12) and in healthy pregnant (n = 13) subjects (all p < 0.05). No further lymphocyte activation was observed in pregnant asthmatics (n = 21) compared either with non-pregnant asthmatic, or pregnant healthy women. Average birth weight of newborns was lower (p < 0.05) in the asthmatic than in the healthy pregnant group. Pregnancy is a state of wide-spread lymphocyte activation but it may blunt lymphocyte activation which characterizes bronchial asthma.

引用

页码：63 / 70

页数：8

共 46 条

[1] Regulatory T cells mediate maternal tolerance to the fetus [J].

Aluvihare, VR ;

Kallikourdis, M ;

Betz, AG .

NATURE IMMUNOLOGY, 2004, 5 (03) :266-271

[2] Autoimmune thyroid disease and pregnancy [J].

Amino, N ;

Tada, H ;

Hidaka, Y .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1996, 19 (01) :59-70

[3]

[Anonymous], 2006, POCK GUID ASTHM MAN

[4]

BARKLAY AN, 1997, LEUKOCYTE ANTIGEN FA

[5] Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone [J].

Beagley, KW ;

Gockel, CM .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2003, 38 (01) :13-22

[6] Pregnancy can induce priming of cytotoxic T lymphocytes specific for paternal HLA antigens that is associated with antibody formation [J].

Bouma, GJ ;

vanCaubergh, P ;

vanBree, SPMJ ;

CastelliVisser, RMC ;

Witvliet, MD ;

vanderMeerPrins, EMW ;

vanRood, JJ ;

Class, FHJ .

TRANSPLANTATION, 1996, 62 (05) :672-678

[7]

Brando B, 2000, CYTOMETRY, V42, P327, DOI 10.1002/1097-0320(20001215)42:6<327::AID-CYTO1000>3.0.CO

[8]

2-F

[9] Prospective study of body mass index, weight change, and risk of adult-onset asthma in women [J].

Camargo, CA ;

Weiss, ST ;

Zhang, SM ;

Willett, WC ;

Speizer, FE .

ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (21) :2582-2588

[10] CD4 T-LYMPHOCYTE ACTIVATION IN ASTHMA IS ACCOMPANIED BY INCREASED SERUM CONCENTRATIONS OF INTERLEUKIN-5 - EFFECT OF GLUCOCORTICOID THERAPY [J].

CORRIGAN, CJ ;

HACZKU, A ;

GEMOUENGESAETH, V ;

DOI, S ;

KIKUCHI, Y ;

TAKATSU, K ;

DURHAM, SR ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (03) :540-547

← 1 2 3 4 5 →