Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms

被引：78

作者：

Li, Haiyang ^{[1
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Jiang, Wenjian ^{[1
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Ren, Weihong ^{[2
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Guo, Dong ^{[1
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Guo, Jialong ^{[1
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Wang, Xiaolong ^{[1
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Liu, Yuyong ^{[1
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Lan, Feng ^{[2
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Du, Jie ^{[1
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Zhang, Hongjia ^{[1
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机构：

[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing 10029, Peoples R China

[2] Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 10029, Peoples R China

[3] Beijing Lab Cardiovasc Precis Med, Beijing 10029, Peoples R China

[4] Minist Educ, Key Lab Remodeling Related Cardiovasc Dis, Beijing 10029, Peoples R China

[5] Beijing Aort Dis Ctr, Cardiovasc Surg Ctr, Beijing 10029, Peoples R China

[6] Beijing Engn Res Ctr Vasc Prostheses, Beijing 10029, Peoples R China

[7] Beijing Collaborat Innovat Ctr Cardiovasc Disorde, Beijing 10029, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

基金：

中国国家自然科学基金;

关键词：

MUSCLE-CELL APOPTOSIS; HUMAN ATHEROSCLEROSIS; MEDIAL DEGENERATION; MECHANICAL STRETCH; YAP; STRESS; PATTERNS;

D O I：

10.1155/2016/6786184

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Previous studies indicate that extracellular matrix (ECM) disorders lead to the apoptosis of Vascular Smooth Muscle Cells (VSMCs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm. The critical role of the Yes-associated protein (YAP) has been elucidated in cardiac/SMC proliferation during cardiovascular development. However, the association of YAP expression and extracellular matrix disorders in ascending aortic aneurysms is not clear. Here, we present for the first time that the downregulation of YAP in VSMCs is associated with ECM disorders of the media in ascending aortic aneurysms. We found that aortic ECM deteriorated with increased apoptotic VSMCs. Moreover, expression of YAP was dramatically reduced in the aortic walls of patients with ascending aortic aneurysms, while the normal aortic samples exhibited abundant YAP in the VSMCs. These results suggest that downregulation of YAP leads to apoptosis of VSMCs, which are essential for the homeostasis of the aortic wall. The resultant ECM disorders affect aortic structure and function and contribute to the development of ascending aortic aneurysms. In summary, through assessment of clinical samples, we revealed the association between downregulation of YAP in VSMCs and the development of ascending aortic aneurysms, providing new insight into the pathogenesis of this disease.

引用

页数：8

共 35 条

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