Cell adhesion: integrating cytoskeletal dynamics and cellular tension

被引：1520

作者：

Parsons, J. Thomas ^{[1
]}

Horwitz, Alan Rick ^{[2
]}

Schwartz, Martin A. ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Microbiol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 09期

关键词：

CALPAIN-MEDIATED PROTEOLYSIS; ACTIN STRESS FIBERS; FOCAL ADHESIONS; MIGRATING CELLS; MATRIX ADHESIONS; ALPHA-ACTININ; RHOA ACTIVITY; MYOSIN-II; TYROSINE PHOSPHORYLATION; PAXILLIN PHOSPHORYLATION;

D O I：

10.1038/nrm2957

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. For most cells in most environments, movement begins with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the substratum, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.

引用

页码：633 / 643

页数：11

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