Design, synthesis, characterization, antioxidant and in vitro cytotoxic activities of novel coumarin thiazole derivatives

A series of novel (Z)-3-(2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl-)hydrazono)indolin-2-one (8a-8d, 9) were synthesized with various substituted indole derivatives. Structures of the newly synthesized compounds were elucidated by FT-IR, H-1 NMR, C-13 NMR and API-ES mass spectral data. In vitro evaluation of these coumarin compounds revealed cytotoxicity from 6.2 to 18 A mu g/mL against CEM, 8.2 to 21 A mu g/mL against L1210, 09 to 19 A mu g/mL against molt 4/C-8, 8.6 to 12 A mu g/mL against HL60 and 8 to 16 A mu g/mL against BEL7402. The antioxidant activity of the synthesized compounds was evaluated by DPPH scavenging method. Compounds 8c, 8d and 9 showed significant antioxidant activity compared with that of standard drug ascorbic acid.