Rh(iii)-Catalyzed C(sp2)-H functionalization/cyclization cascade of N-carboxamide indole and iodonium reagents for access to indoloquinazolinone derivatives

被引：45

作者：

Han, Zhi-Peng ^{[1
,2
]}

Xu, Meng-Meng ^{[1
,2
]}

Zhang, Rui-Ying ^{[1
,2
]}

Xu, Xiao-Ping ^{[1
,2
,3
]}

Ji, Shun-Jun ^{[1
,2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China

[3] Soochow Univ, Innovat Ctr Chem Sci, Suzhou, Peoples R China

来源：

GREEN CHEMISTRY | 2021年 / 23卷 / 17期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; C-H ACTIVATION; PHENYLIODONIUM YLIDE; ALKALOIDS; CYCLOPROPANATION; QUINAZOLINE; ANNULATIONS; CYCLIZATION; SKELETONS; CARBENES;

D O I：

10.1039/d1gc01820e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rhodium-catalyzed synthesis of indoloquinazolinone from a readily available hypervalent iodonium reagent and N-carboxamide indole was developed. The protocol features broad functional group tolerance, mild conditions, and excellent yields. The target products were obtained simply by filtration, without tedious column chromatography. Notably, the noble metal catalyst system can be recycled effectively at least ten times. The strategy may be amenable to industrial production.

引用

页码：6337 / 6340

页数：4

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